530
Participants
Start Date
July 31, 2014
Primary Completion Date
July 31, 2022
Study Completion Date
January 31, 2025
FOLFOX/ FOLFIRI with bevacizumab
"FOLFIRI + bevacizumab Bevacizumab 5 mg/kg in 15-30 minutes i.v., followed by irinotecan 180 mg/m2 i.v. in 60 minutes together with leucovorin 400 mg/m2 i.v. in 120 minutes, followed by bolus 5-fluorouracil 400 mg/m2 within 4 minutes, all on day 1, followed by continuous infusion of 5-fluorouracil 2400 mg/m2 in 46 hours, every 2 weeks~FOLFOX6 + bevacizumab Bevacizumab 5 mg/kg in 15-30 minutes i.v., followed by oxaliplatin 85 mg/m2 i.v. together with leucovorin 400 mg/m2 i.v. in 120 minutes, followed by bolus 5FU 400 mg/m2 within 4 minutes, all on day 1, followed by continuous infusion of 5-fluorouracil 2400 mg/m2 in 46 hours, every 2 weeks"
FOLFOXIRI with bevacizumab
FOLFOXIRI + bevacizumab Bevacizumab 5 mg/kg in 15-30 minutes i.v., followed by irinotecan 165 mg/m2 i.v. in 60 minutes, followed by oxaliplatin 85 mg/m2 i.v. together with leucovorin 400 mg/m2 i.v. in 120 minutes, followed by continuous infusion of 5-fluorouracil 3200 mg/m2 in 46 hours, every 2 weeks
FOLFOX/ FOLFIRI with panitumumab
"FOLFIRI + panitumumab Panitumumab 6 mg/kg i.v. (1st dose in 60 minutes, if well tolerated subsequent doses in 30 minutes), followed by irinotecan 180 mg/m2 i.v. in 60 minutes together with leucovorin 400 mg/m2 i.v. in 120 minutes, followed by bolus 5-fluorouracil 400 mg/m2 within 4 minutes, all on day 1, followed by continuous infusion of 5-fluorouracil 2400 mg/m2 in 46 hours, every 2 weeks~FOLFOX6 + panitumumab Panitumumab 6 mg/kg i.v. (1st dose in 60 minutes, if well tolerated subsequent doses in 30 minutes), followed by oxaliplatin 85 mg/m2 i.v. together with leucovorin 400 mg/m2 i.v. in 120 minutes, and bolus 5FU 400 mg/m2 within 4 minutes, all on day 1, followed by continuous infusion of 5-fluorouracil 2400 mg/m2 in 46 hours, every 2 weeks"
Universitair ziekenhuis Antwerpen, Antwerp
Flevoziekenhuis, Almere Stad
Gelre Ziekenhuis, Apeldoorn
Rijnstate ziekenhuis, Arnhem
Sint Jansdal Ziekenhuis, Harderwijk
Radboud UMC, Nijmegen
Streekziekenhuis Koningin Beatrix, Winterswijk
Atrium Medical Center, Heerlen
Maastricht UMC+, Maastricht
Laurentius Ziekenhuis, Roermond
Orbis Medical Center, Sittard
VieCuri Medisch Centrum, Venlo
Jeroen Bosch Ziekenhuis, 's-Hertogenbosch
Bravis Ziekenhuis, Bergen op Zoom
Amphia Ziekenhuis, Breda
Elkerliek Ziekenhuis, Helmond
Bravis Ziekenhuis, Roosendaal
Sint Elisabeth Ziekenhuis, Tilburg
TweeSteden Ziekenhuis, Tilburg
Bernhoven, Uden
Maxima Medisch Centrum, loc. Veldhoven, Veldhoven
Medisch Centrum Alkmaar, Alkmaar
Amsterdam UMC, location VUMC, Amsterdam
Antoni van Leeuwenhoek, Amsterdam
BovenIJ Ziekenhuis, Amsterdam
OLVG, locatie Oost, Amsterdam
OLVG, locatie West, Amsterdam
Spaarne Gasthuis, Haarlem
Tergooi, Hilversum
Spaarne ziekenhuis, Hoofddorp
Waterlandziekenhuis, Purmerend
Zaans Medical Center, Zaandam
Deventer Ziekenhuis, Deventer
Medisch Spectrum Twente, Enschede
Ziekenhuisgroep Twente, Hengelo
Isala Klinieken, Zwolle
Ziekenhuis Nij Smellinghe, Drachten
Medisch Centrum Leeuwarden, loc. Zuid, Leeuwarden
Antonius Ziekenhuis, Sneek
Martini Ziekenhuis, Groningen
UMC Groningen, Groningen
Reinier de Graaf, Delft
Albert Schweitzer Ziekenhuis, Dordrecht
LUMC, Leiden
Erasmus MC, Rotterdam
Ikazia Ziekenhuis, Rotterdam
Maasstad Ziekenhuis, Rotterdam
Sint Franciscus Gasthuis, Rotterdam
Franciscus Vlietland, Schiedam
Hagaziekenhuis, The Hague
Medisch Centrum Haaglanden, Westeinde, The Hague
UMC Utrecht, Utrecht
Meander Medisch Centrum, Amersfoort
Sint Antonius Ziekenhuis, Nieuwegein
Admiraal de Ruyter ziekenhuis, Goes
Amsterdam UMC, location AMC, Amsterdam
Dutch Colorectal Cancer Group
OTHER