Effectiveness of Routine Nebulization of Mucolytics and Bronchodilators During Mechanical Ventilation

NACompletedINTERVENTIONAL
Enrollment

950

Participants

Timeline

Start Date

July 31, 2014

Primary Completion Date

March 31, 2017

Study Completion Date

June 30, 2017

Conditions
Respiratory Failure
Interventions
DRUG

acetylcysteine and salbutamol

routine nebulisation of a 3 mL-solution of acetylcysteine (fluimucil 100mg/ml) and a 2.5 mL solution containing salbutamol (ventolin 2.5 Nebules 2.5mg/2.5 ml) four times daily

DRUG

acetylcysteine

nebulisation of acetylcysteine on strict clinical indications only', i.e. in case of occurrence of persistent thick and tenacious sputum

DRUG

salbutamol

nebulisation of salbutamol on strict clinical indications only', i.e. in case of occurrence of bronchospasm

Trial Locations (7)

4818 CK

Amphia Ziekenhuis Breda, Breda

1090 HM

Onze Lieve Vrouwe Gasthuis, Amsterdam

1105 AZ

Academic Medical Center, Amsterdam

8025BT

Isala, Zwolle

3430 EM

Sint Antonius Ziekenhuis, Nieuwegein

6815 AD

Rijnstate Ziekenhuis, Arnhem

2512 VA

MC Haaglanden, The Hague

All Listed Sponsors
collaborator

ZonMw: The Netherlands Organisation for Health Research and Development

OTHER

lead

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

OTHER

NCT02159196 - Effectiveness of Routine Nebulization of Mucolytics and Bronchodilators During Mechanical Ventilation | Biotech Hunter | Biotech Hunter