Individualized Perioperative Open Lung Ventilatory Strategy

NACompletedINTERVENTIONAL
Enrollment

920

Participants

Timeline

Start Date

September 30, 2014

Primary Completion Date

April 30, 2016

Study Completion Date

April 30, 2016

Conditions
Moderated-high Risk of Postoperative Pulmonary ComplicationAbdominal Surgery Expected More Than Two Hours
Interventions
PROCEDURE

Alveolar recruitment maneuver

To start Alveolar Recruitment Maneuver (ARM), change ventilatory pressure-controlled mode (PCV) with 15 cmH2O pressure control ventilation. A respiratory rate (RR) of 15 rpm, inspiration: expiration ratio of 1:1, FiO2 of 0.8 and PEEP of 10 cmH2O. PEEP level will increase 5 on 5 cmH2O every 10 respiratory cycles, increasing to 15 cycles in the last level of PEEP (25 cmH2O), getting an opening pressure at 40 cmH2O airway (duration of the maneuver: 160 sec.)

PROCEDURE

Calculation of optimal PEEP

Change ventilation mode to volume controlled ventilation (VCV) with a VT of 8 ml / kg, RR 15 rpm and adjust a PEEP of 20 cmH2O. Descend PEEP level 2 by 2 cmH2O every 30 seconds until obtain the best respiratory system compliance (Crs) PEEP. Once you know the optimal level of PEEP (best Crs PEEP), will be conducted again alveolar recruitment maneuver and adjust the best Crs level of PEEP + 2 cmH2O .

PROCEDURE

Postoperative CPAP

Postoperatively, non-invasive mechanical ventilation with a CPAP of 5 cmH2O (or 10 cmH2O if BMI\> 30) with a FiO2 of 0.5 will be applied.

Trial Locations (7)

7600

Hospital Privado de la Comunidad, Mar del Plata

28007

Hospital Gregorio Marañón, Madrid

46010

Department of Anesthesia and Critical Care; Hospital Clinico Universitario, Valencia

MA 02114

Massachusetts General Hospital, Boston

08916

Hospital Germans Trias i Pujol, Badalona

08026

Hospital de la Santa Creu i Sant Pau, Barcelona

Unknown

Uppsala University Hospital, Uppsala

All Listed Sponsors
collaborator

Hospital de Manises

OTHER

collaborator

Hospital General Valencia

OTHER

collaborator

Hospital Universitario La Fe

OTHER

collaborator

Germans Trias i Pujol Hospital

OTHER

collaborator

Hospital de Sant Pau

OTHER

collaborator

Hospital del Mar

OTHER

collaborator

Fundación de Investigación Biomédica - Hospital Universitario de La Princesa

OTHER

collaborator

Hospital General Universitario Gregorio Marañon

OTHER

collaborator

Hospital General Universitario de Alicante

OTHER

collaborator

Hospital Juan Canalejo

OTHER

collaborator

Hospital General Regional de León

OTHER_GOV

collaborator

Hospital Universitario Virgen de la Arrixaca

OTHER

collaborator

Hospital Miguel Servet

OTHER

collaborator

Hospital Clínico Universitario de Valladolid

OTHER

collaborator

Hospital Universitario Fundación Alcorcón

OTHER

collaborator

Hospital General de Ciudad Real

OTHER

collaborator

Hospital Universitario de Valme

OTHER

collaborator

Hospital de Basurto

OTHER

collaborator

Hospital Dr. Negrín

UNKNOWN

collaborator

Hospital de Galdakano

UNKNOWN

collaborator

Complejo Hospitalario de Especialidades Juan Ramón Jimenez

OTHER

collaborator

Puerta de Hierro University Hospital

OTHER

lead

Fundación para la Investigación del Hospital Clínico de Valencia

OTHER

NCT02158923 - Individualized Perioperative Open Lung Ventilatory Strategy | Biotech Hunter | Biotech Hunter