2
Participants
Start Date
February 28, 2015
Primary Completion Date
June 22, 2021
Study Completion Date
June 22, 2021
Tacrolimus
Tacrolimus starting on Day -1
Equine Anti-thymocyte globulin
20 mg/kg IV on Days -3, -1, +1, +3
Kidney transplant from a related donor
On Day 0 the renal transplant is performed according to standard surgical techniques.
Bone marrow transplant from a related donor
Donor bone marrow (\> 2 x 10e8 nucleated cells/kg of recipient body weight) is prepared for infusion according to the standard procedure. The infusion begins in the operating room as soon as the vascular anastomosis of the renal allograft has been completed.
Total body irradiation 400 centigray (200 cGy X 2)
On transplant day -1
Massachusetts General Hospital, Boston
Massachusetts General Hospital
OTHER