Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location

PHASE3CompletedINTERVENTIONAL
Enrollment

255

Participants

Timeline

Start Date

July 25, 2014

Primary Completion Date

August 31, 2019

Study Completion Date

August 19, 2019

Conditions
Persistent Pregnancy of Unknown LocationEctopic Pregnancy
Interventions
DRUG

Methotrexate

Two Dose Protocol: The patient will receive the first dose of MTX 50mg/m2 on treatment day 0. She will receive a second dose of MTX 50mg/m2 on treatment day 4 and a serum hCG level will be drawn. Subsequent doses of MTX will be administered based on hCG levels.

PROCEDURE

Uterine Evacuation

Uterine evacuation or dilation and curettage. At the clinician's discretion, this can be performed using local anesthesia, sedation or general anesthesia and can use a manual or electrical evacuation.

OTHER

Expectant Management

Pregnancy will be expectantly managed using serum hcg monitoring

Trial Locations (17)

14642

University of Rochester, Rochester

19104

University of Pennsylvania, Philadelphia

27599

University of North Carolina, Chapel Hill

27708

Duke University, Durham

28204

Carolinas Medical Center - Women's Institute, Charlotte

29605

Greenville Health System, Greenville

30912

Augusta University, Augusta

33606

University of South Florida, Tampa

48034

Wayne State University, Southfield

60611

Northwestern University, Chicago

60612

University Of Illinois at Chicago, Chicago

63108

Washington University, St Louis

73104

University of Oklahoma, Oklahoma City

80204

Denver Health, Denver

84132

University of Utah, Salt Lake City

94115

University of California San Francisco, San Francisco

06520

Yale University, New Haven

All Listed Sponsors
collaborator

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NIH

collaborator

Augusta University

OTHER

collaborator

Penn State University

OTHER

collaborator

University of California, San Francisco

OTHER

collaborator

University of North Carolina

OTHER

collaborator

University of Oklahoma

OTHER

collaborator

University of Pennsylvania

OTHER

lead

Yale University

OTHER

NCT02152696 - Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location | Biotech Hunter | Biotech Hunter