3
Participants
Start Date
May 31, 2014
Primary Completion Date
February 28, 2018
Study Completion Date
February 28, 2018
Endotoxin (E. coli O:113, Reference Endotoxin)
The endotoxin will be reconstituted with sterile water to a final concentration of 2,000 endotoxin units/ml. The dose of 4 ng/kg will be prepared to a final volume of 2 ml and will be administered using a 5F balloon-tipped monitoring catheter inserted via a fiberoptic bronchoscope into the lateral segment of the right middle lobe of the lung on the morning of Day 2.
[18F](+/-)NOS
7 mCi of \[18F\](+/-)NOS will be injected intravenously at the start of a 60-minute dynamic PET scan acquisition
Washington University School of Medicine / Barnes-Jewish Hospital, St Louis
Doris Duke Charitable Foundation
OTHER
Washington University School of Medicine
OTHER