52
Participants
Start Date
January 31, 2012
Primary Completion Date
August 31, 2013
Study Completion Date
August 31, 2013
Forearm venous occlusion plethysmography
Forearm venous occlusion plethysmography to study to measure forearm blood flow during intra-arterial infusion of the apelin peptides.
Aellig hand vein technique
Hand vein measurements will be used to assess the response to apelin peptides and apelin receptor blocker in the human hand vein vascular bed.
Apelin agonist infusion
Escalating doses of apelin (1/10/100nmol/min) will be administered.
Apelin receptor antagonist infusion
Dose finding study (range 1-300nmol/min) and co-infusion study with apelin peptides
Vascular Research Unit, Cambridge
University of Cambridge
OTHER