Concurrent Cisplatin Chemoradiation With or Without Capecitabine as Adjuvant Chemotherapy in Local Advanced High Risk Nasopharyngeal Carcinoma: Randomized Control Clinical Trial

PHASE3CompletedINTERVENTIONAL
Enrollment

180

Participants

Timeline

Start Date

March 31, 2014

Primary Completion Date

July 27, 2018

Study Completion Date

August 5, 2022

Conditions
Local Advanced High Risk Nasopharyngeal Carcinoma
Interventions
DRUG

IMRT combine with cisplatin concurrent chemotherapy

Patients in the control arm received radical radiotherapy with IMRT, and cisplatin (100mg/m2 on day 1) every three weeks for three cycles during RT.

DRUG

IMRT combine with cisplatin concurrent chemotherapy plus capecitabine adjuvant chemotherapy

Patients in the experimental arm received radical radiotherapy with IMRT, and cisplatin (100mg/m2 on day 1) every three weeks for three cycles during RT,followed by adjuvant chemotherapy with oral capecitabine(1000mg/m2/ twice a day for 14 days)every three weeks for eight cycles.

Trial Locations (1)

Unknown

Cancer Center, Sun Yat-sen University, Guangzhou

All Listed Sponsors
collaborator

Jiangxi Provincial Cancer Hospital

OTHER

collaborator

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

OTHER

collaborator

National Cancer Centre, Singapore

OTHER

lead

Zhao Chong

OTHER

NCT02143388 - Concurrent Cisplatin Chemoradiation With or Without Capecitabine as Adjuvant Chemotherapy in Local Advanced High Risk Nasopharyngeal Carcinoma: Randomized Control Clinical Trial | Biotech Hunter | Biotech Hunter