Efficacy and Safety Study of FP MDPI Compared With FS MDPI in Adolescent and Adult Patients With Persistent Asthma

PHASE3CompletedINTERVENTIONAL
Enrollment

882

Participants

Timeline

Start Date

June 30, 2014

Primary Completion Date

September 30, 2015

Study Completion Date

September 30, 2015

Conditions
Asthma
Interventions
DRUG

FS MDPI

"FS MDPI is an inhalation-driven multidose dry powder inhaler (MDPI) containing fluticasone propionate and salmeterol xinafoate dispersed in a lactose monohydrate excipient and contained within a reservoir. A metered dose of drug is delivered to a dose cup via an air pulse activated when the cap is opened.~During the treatment period, participants were randomized to either fluticasone propionate/salmeterol MDPI 200/12.5 mcg or fluticasone propionate/salmeterol MDPI 100/12.5 mcg twice a day for a total daily dose of 200/25 mcg or 400/25 mcg.~Participants were instructed to rinse their mouth and expectorate (not swallow) after study drug administration."

DRUG

Fp MDPI

"Fp MDPI is an inhalation-driven multidose dry powder inhaler (MDPI) containing fluticasone propionate (Fp) dispersed in a lactose monohydrate excipient and contained within a reservoir. A metered dose of drug is delivered to a dose cup via an air pulse activated when the cap is opened.~During the treatment period, participants were randomized to either 200 mcg or 100 mcg of Fp one inhalation twice a day for a total daily dose of 400 mcg or 200 mcg.~Participants were instructed to rinse their mouth and expectorate (not swallow) after study drug administration."

DRUG

Placebo MDPI

The placebo multidose dry powder inhaler (MDPI) was identical to the devices used to deliver active drug, and indistinguishable from the active treatments. Patients took one inhalation twice a day (approximately 12 hours apart). Patients were instructed to rinse their mouth and expectorate (not swallow) after study drug administration.

DRUG

Albuterol/salmeterol HFA MDI

Albuterol/salmeterol hydrofluoroalkane (HFA) metered dose inhaler (MDI) was supplied to participants throughout the study to be used as needed as a rescue medication.

Trial Locations (154)

Unknown

Teva Investigational Site 12429, Birmingham

Teva Investigational Site 12599, Little Rock

Teva Investigational Site 12609, Phoenix

Teva Investigational Site 12445, Costa Mesa

Teva Investigational Site 12454, Encinitas

Teva Investigational Site 12456, Fresno

Teva Investigational Site 12461, Fullerton

Teva Investigational Site 12410, Huntington Beach

Teva Investigational Site 12452, Huntington Beach

Teva Investigational Site 12417, Long Beach

Teva Investigational Site 13017, Mission Viejo

Teva Investigational Site 12462, Rancho Mirage

Teva Investigational Site 12411, Rolling Hills Estates

Teva Investigational Site 13018, San Diego

Teva Investigational Site 12413, San Jose

Teva Investigational Site 12403, Stockton

Teva Investigational Site 12444, Upland

Teva Investigational Site 12999, Vista

Teva Investigational Site 12405, Centennial

Teva Investigational Site 12419, Centennial

Teva Investigational Site 13000, Colorado Springs

Teva Investigational Site 12459, Waterbury

Teva Investigational Site 13004, Largo

Teva Investigational Site 12414, Miami

Teva Investigational Site 12437, Miami

Teva Investigational Site 12427, Orlando

Teva Investigational Site 12423, Ormond Beach

Teva Investigational Site 12604, Panama City

Teva Investigational Site 13316, Tamarac

Teva Investigational Site 12606, Winter Park

Teva Investigational Site 12435, Savannah

Teva Investigational Site 13315, Eagle

Teva Investigational Site 12439, River Forest

Teva Investigational Site 12449, Shiloh

Teva Investigational Site 12457, South Bend

Teva Investigational Site 12446, Bangor

Teva Investigational Site 12602, Columbia

Teva Investigational Site 12432, Fall River

Teva Investigational Site 12441, North Dartmouth

Teva Investigational Site 12466, North Dartmouth

Teva Investigational Site 13001, Royal Oak

Teva Investigational Site 12428, Ypsilanti

Teva Investigational Site 13020, Minneapolis

Teva Investigational Site 12451, Columbia

Teva Investigational Site 12421, Rolla

Teva Investigational Site 12412, St Louis

Teva Investigational Site 12453, St Louis

Teva Investigational Site 12610, Missoula

Teva Investigational Site 13021, Las Vegas

Teva Investigational Site 12409, Skillman

Teva Investigational Site 12464, Brooklyn

Teva Investigational Site 12603, The Bronx

Teva Investigational Site 12430, Charlotte

Teva Investigational Site 12407, Raleigh

Teva Investigational Site 12415, Canton

Teva Investigational Site 12455, Cincinnati

Teva Investigational Site 12463, Cincinnati

Teva Investigational Site 12460, Middleburg Heights

Teva Investigational Site 12426, Edmond

Teva Investigational Site 13008, Oklahoma City

Teva Investigational Site 12406, Medford

Teva Investigational Site 12442, Portland

Teva Investigational Site 12563, Normal Square

Teva Investigational Site 12443, Pittsburgh

Teva Investigational Site 12438, Upland

Teva Investigational Site 12408, Charleston

Teva Investigational Site 12431, Greenville

Teva Investigational Site 12465, Mt. Pleasant

Teva Investigational Site 12467, Mt. Pleasant

Teva Investigational Site 12420, Orangeburg

Teva Investigational Site 12433, Rock Hill

Teva Investigational Site 13003, Knoxville

Teva Investigational Site 12425, Arlington

Teva Investigational Site 12416, Dallas

Teva Investigational Site 12418, Dallas

Teva Investigational Site 12440, El Paso

Teva Investigational Site 12447, Killeen

Teva Investigational Site 13318, San Antonio

Teva Investigational Site 13002, Sugar Land

Teva Investigational Site 12424, Waco

Teva Investigational Site 12422, South Burlington

Teva Investigational Site 12605, Richmond

Teva Investigational Site 12436, Spokane

Teva Investigational Site 12564, Tacoma

Teva Investigational Site 12448, Greenfield

Teva Investigational Site 11072, Toronto

Teva Investigational Site 11075, Vancouver

Teva Investigational Site 54096, Jindřichův Hradec

Teva Investigational Site 54098, Prague

Teva Investigational Site 54095, Rokycany

Teva Investigational Site 54094, Strakonice

Teva Investigational Site 51149, Budapest

Teva Investigational Site 51155, Budapest

Teva Investigational Site 51157, Budapest

Teva Investigational Site 51161, Budapest

Teva Investigational Site 51154, Debrecen

Teva Investigational Site 51152, Deszk

Teva Investigational Site 51170, Dombóvár

Teva Investigational Site 51158, Kiskunhalas

Teva Investigational Site 51153, Miskolc

Teva Investigational Site 51156, Mosdós

Teva Investigational Site 51150, Nyíregyháza

Teva Investigational Site 51151, Nyíregyháza

Teva Investigational Site 51148, Százhalombatta

Teva Investigational Site 51146, Szeged

Teva Investigational Site 51162, Szigetvár

Teva Investigational Site 51147, Szombathely

Teva Investigational Site 51176, Tatabánya

Teva Investigational Site 51177, Törökbálint

Teva Investigational Site 53199, Bialystok

Teva Investigational Site 53200, Bialystok

Teva Investigational Site 53202, Bialystok

Teva Investigational Site 53208, Bialystok

Teva Investigational Site 53210, Bydgoszcz

Teva Investigational Site 53227, Bydgoszcz

Teva Investigational Site 53225, Dębica

Teva Investigational Site 53203, Gdansk

Teva Investigational Site 53195, Krakow

Teva Investigational Site 53197, Krakow

Teva Investigational Site 53205, Krakow

Teva Investigational Site 53228, Lodz

Teva Investigational Site 53240, Lodz

Teva Investigational Site 53201, Lódz

Teva Investigational Site 53229, Lódz

Teva Investigational Site 53241, Lublin

Teva Investigational Site 53206, Poznan

Teva Investigational Site 53211, Poznan

Teva Investigational Site 53230, Strzelce Opolskie

Teva Investigational Site 53196, Tarnów

Teva Investigational Site 53222, Warsaw

Teva Investigational Site 53198, Wroclaw

Teva Investigational Site 53224, Wroclaw

Teva Investigational Site 50255, Chelyabinsk

Teva Investigational Site 50241, Kazan'

Teva Investigational Site 50250, Moscow

Teva Investigational Site 50252, Moscow

Teva Investigational Site 50242, Saint Petersburg

Teva Investigational Site 50245, Saint Petersburg

Teva Investigational Site 50246, Saint Petersburg

Teva Investigational Site 50254, Saratov

Teva Investigational Site 50244, Tomsk

Teva Investigational Site 50251, Voronezh

Teva Investigational Site 50275, Yaroslavl

Teva Investigational Site 50243, Yekaterinburg

Teva Investigational Site 90011, Berea

Teva Investigational Site 90015, Bloemfontein

Teva Investigational Site 90012, Cape Town

Teva Investigational Site 90013, Centurion

Teva Investigational Site 90016, Middelburg

Teva Investigational Site 90014, Pretoria

Teva Investigational Site 12404, Papillion

Teva Investigational Site 58133, Kharkiv

Teva Investigational Site 58135, Kharkiv

Teva Investigational Site 58132, Kyiv

All Listed Sponsors
lead

Teva Branded Pharmaceutical Products R&D, Inc.

INDUSTRY

NCT02141854 - Efficacy and Safety Study of FP MDPI Compared With FS MDPI in Adolescent and Adult Patients With Persistent Asthma | Biotech Hunter | Biotech Hunter