A Phase 2 Open-Label Study of the Efficacy and Safety of ABT-199 (GDC-0199) in Chronic Lymphocytic Leukemia (CLL) Subjects With Relapse or Refractory to B-Cell Receptor Signaling Pathway Inhibitor Therapy

PHASE2CompletedINTERVENTIONAL
Enrollment

127

Participants

Timeline

Start Date

September 10, 2014

Primary Completion Date

December 22, 2021

Study Completion Date

December 22, 2021

Conditions
Chronic Lymphocytic Leukemia
Interventions
DRUG

Venetoclax

Each dose of venetoclax was to be taken with approximately 240 mL of water within 30 minutes after the completion of breakfast or the participant's first meal of the day.

Trial Locations (15)

14642

Univ Rochester Med Ctr /ID# 130011, Rochester

20007

Georgetown University Hospital /ID# 127261, Washington D.C.

30322

Emory Midtown Infectious Disease Clinic /ID# 131249, Atlanta

43210

The Ohio State University /ID# 127263, Columbus

77030

University of Texas MD Anderson Cancer Center /ID# 126498, Houston

90095

University of California, Los Angeles /ID# 127262, Los Angeles

92093

Moores Cancer Center at UC San Diego /ID# 128535, La Jolla

94305-2200

Stanford University School of Med /ID# 126495, Stanford

60611-2927

Northwestern University Feinberg School of Medicine /ID# 126497, Chicago

02215-5400

Beth Israel Deaconess Medical Center /ID# 134509, Boston

02215

Dana-Farber Cancer Institute /ID# 126496, Boston

10032-3725

Columbia Univ Medical Center /ID# 128536, New York

New York Presbyterian Hospital Weill Cornell Medical Center /ID# 129648, New York

19104-5502

University of Pennsylvania /ID# 126860, Philadelphia

84112-5500

University of Utah /ID# 130813, Salt Lake City

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Roche-Genentech

INDUSTRY

lead

AbbVie

INDUSTRY