Study of Fluticasone Propionate MDPI Compared With Fluticasone/Salmeterol MDPI in Adolescent and Adult Patients With Persistent Asthma

PHASE3CompletedINTERVENTIONAL
Enrollment

787

Participants

Timeline

Start Date

June 30, 2014

Primary Completion Date

September 30, 2015

Study Completion Date

September 30, 2015

Conditions
Asthma
Interventions
DRUG

FS MDPI

"FS MDPI is an inhalation-driven multidose dry powder inhaler (MDPI) containing fluticasone propionate (Fp) and salmeterol xinafoate (Sx) dispersed in a lactose monohydrate excipient and contained within a reservoir. A metered dose of drug is delivered to a dose cup via an air pulse activated when the cap is opened.~During the treatment period, participants were randomized to either 100/12.5 mcg Fp/Sx or 50/12.5 mcg Fp/Sx in the morning and evening for a total daily dose of 200/25 mcg or 100/25 mcg Fp/Sx.~Participants were instructed to rinse their mouth and expectorate (not swallow) after study drug administration."

DRUG

Fp MDPI

"Fp MDPI is an inhalation-driven multidose dry powder inhaler (MDPI) containing fluticasone propionate dispersed in a lactose monohydrate excipient and contained within a reservoir. A metered dose of drug is delivered to a dose cup via an air pulse activated when the cap is opened.~During the treatment period, participants were randomized to either 100 mcg or 50 mcg of Fp one inhalation twice a day for a total daily dose of 200 mcg or 100 mcg.~Participants were instructed to rinse their mouth and expectorate (not swallow) after study drug administration."

DRUG

Placebo MDPI

Placebo administered via a multidose dry powder inhaler (MDPI) one puff in the morning and one puff in the evening for 12 weeks.

DRUG

albuterol/salbutamol

A short-acting β2-adrenergic agonists (SABA), albuterol/salbutamol hydrofluoroalkane (HFA) metered dose inhaler (MDI), was provided to be used as needed for the relief of asthma symptoms during both the run-in and treatment periods (to replace the subject's current rescue medication).

DRUG

Beclomethasone dipropionate

QVAR (beclomethasone dipropionate) 40 mcg inhalation aerosol is a pressurized MDI that contains a Food and Drug Administration (FDA)-approved formulation of beclomethasone dipropionate. Patients took 1 puff twice a day from open-label QVAR 40 mcg hydrofluoroalkane (specifically, HFA-134a) metered-dose inhaler (MDI) for the duration of the Run-in Period (14-21 days) and prior to randomization. A clinically equivalent dose of inhaled corticosteroid (ICS) was substituted in countries where QVAR 40 mcg was not available.

Trial Locations (140)

Unknown

Teva Investigational Site 12397, Birmingham

Teva Investigational Site 12375, Glendale

Teva Investigational Site 12395, Cypress

Teva Investigational Site 12476, Encinitas

Teva Investigational Site 12586, Fountain Valley

Teva Investigational Site 12591, Fresno

Teva Investigational Site 12372, Huntington Beach

Teva Investigational Site 12365, Los Angeles

Teva Investigational Site 12381, Los Angeles

Teva Investigational Site 12401, Los Angeles

Teva Investigational Site 12394, Mission Viejo

Teva Investigational Site 12490, Rancho Mirage

Teva Investigational Site 12393, Riverside

Teva Investigational Site 12366, Rolling Hills Estates

Teva Investigational Site 12383, San Diego

Teva Investigational Site 12370, San Jose

Teva Investigational Site 12371, Stockton

Teva Investigational Site 12579, Upland

Teva Investigational Site 12379, Centennial

Teva Investigational Site 12386, Centennial

Teva Investigational Site 12596, Colorado Springs

Teva Investigational Site 12584, Longmont

Teva Investigational Site 12484, Waterbury

Teva Investigational Site 12590, Waterbury

Teva Investigational Site 12493, Clearwater

Teva Investigational Site 12992, Largo

Teva Investigational Site 12376, Miami

Teva Investigational Site 12390, Miami

Teva Investigational Site 12583, Orlando

Teva Investigational Site 12481, Tallahassee

Teva Investigational Site 12491, Winter Park

Teva Investigational Site 12997, Decatur

Teva Investigational Site 12392, Savannah

Teva Investigational Site 12592, Shiloh

Teva Investigational Site 12483, Lenexa

Teva Investigational Site 12399, Baltimore

Teva Investigational Site 12391, Bethesda

Teva Investigational Site 12589, Columbia

Teva Investigational Site 12369, Rockville

Teva Investigational Site 12396, Fall River

Teva Investigational Site 12384, North Dartmouth

Teva Investigational Site 12585, North Dartmouth

Teva Investigational Site 12588, Ypsilanti

Teva Investigational Site 12494, St Louis

Teva Investigational Site 12595, St Louis

Teva Investigational Site 12594, Missoula

Teva Investigational Site 12385, Ocean City

Teva Investigational Site 12380, Skillman

Teva Investigational Site 12587, Brooklyn

Teva Investigational Site 12485, Rockville Centre

Teva Investigational Site 12475, Huntersville

Teva Investigational Site 12364, Raleigh

Teva Investigational Site 12374, Canton

Teva Investigational Site 12480, Cincinnati

Teva Investigational Site 12492, Cincinnati

Teva Investigational Site 12487, Middleburg Heights

Teva Investigational Site 12488, Sylvania

Teva Investigational Site 12377, Edmond

Teva Investigational Site 12368, Medford

Teva Investigational Site 12382, Portland

Teva Investigational Site 12400, Pittsburgh

Teva Investigational Site 12473, Upland

Teva Investigational Site 12389, Greenville

Teva Investigational Site 12580, Mt. Pleasant

Teva Investigational Site 12398, Orangeburg

Teva Investigational Site 12991, Knoxville

Teva Investigational Site 12990, Cypress

Teva Investigational Site 12373, Dallas

Teva Investigational Site 12402, El Paso

Teva Investigational Site 12582, New Braunfels

Teva Investigational Site 12363, San Antonio

Teva Investigational Site 12482, San Antonio

Teva Investigational Site 12477, Waco

Teva Investigational Site 12478, Murray

Teva Investigational Site 12388, South Burlington

Teva Investigational Site 12378, Milwaukee

Teva Investigational Site 11065, Toronto

Teva Investigational Site 11067, Montreal

Teva Investigational Site 11068, Vancouver

Teva Investigational Site 54084, Neratovice

Teva Investigational Site 54088, Prague

Teva Investigational Site 54087, Rokycany

Teva Investigational Site 51134, Budapest

Teva Investigational Site 51143, Budapest

Teva Investigational Site 51144, Budapest

Teva Investigational Site 51140, Debrecen

Teva Investigational Site 51142, Deszk

Teva Investigational Site 51165, Dombóvár

Teva Investigational Site 51145, Kiskunhalas

Teva Investigational Site 51141, Miskolc

Teva Investigational Site 51133, Mosdós

Teva Investigational Site 51136, Nyíregyháza

Teva Investigational Site 51139, Nyíregyháza

Teva Investigational Site 51163, Sopron

Teva Investigational Site 51137, Szeged

Teva Investigational Site 51164, Szigetvár

Teva Investigational Site 51138, Szombathely

Teva Investigational Site 53182, Bialystok

Teva Investigational Site 53183, Bialystok

Teva Investigational Site 53185, Bialystok

Teva Investigational Site 53191, Bialystok

Teva Investigational Site 53187, Bienkówka

Teva Investigational Site 53219, Bydgoszcz

Teva Investigational Site 53217, Dębica

Teva Investigational Site 53178, Krakow

Teva Investigational Site 53180, Krakow

Teva Investigational Site 53188, Krakow

Teva Investigational Site 53220, Lodz

Teva Investigational Site 53235, Lodz

Teva Investigational Site 53221, Lódz

Teva Investigational Site 53237, Lublin

Teva Investigational Site 53194, Poznan

Teva Investigational Site 53234, Poznan

Teva Investigational Site 53233, Strzelce Opolskie

Teva Investigational Site 53179, Tarnów

Teva Investigational Site 53218, Tarnów

Teva Investigational Site 53193, Warsaw

Teva Investigational Site 53181, Wroclaw

Teva Investigational Site 53189, Wroclaw

Teva Investigational Site 50236, Chelyabinsk

Teva Investigational Site 50227, Kazan'

Teva Investigational Site 50234, Moscow

Teva Investigational Site 50238, Moscow

Teva Investigational Site 50230, Novosibirsk

Teva Investigational Site 50224, Saint Petersburg

Teva Investigational Site 50231, Saint Petersburg

Teva Investigational Site 50233, Voronezh

Teva Investigational Site 50237, Yaroslavl

Teva Investigational Site 50226, Yekaterinburg

Teva Investigational Site 90002, Cape Town

Teva Investigational Site 90008, Cape Town

Teva Investigational Site 90005, Centurion

Teva Investigational Site 90001, Johannesburg

Teva Investigational Site 90003, Middelburg

Teva Investigational Site 90007, Pretoria

Teva Investigational Site 58125, Kharkiv

Teva Investigational Site 58126, Kharkiv

Teva Investigational Site 58127, Kyiv

Teva Investigational Site 58128, Kyiv

Teva Investigational Site 58129, Vinnytsia

All Listed Sponsors
lead

Teva Branded Pharmaceutical Products R&D, Inc.

INDUSTRY

NCT02139644 - Study of Fluticasone Propionate MDPI Compared With Fluticasone/Salmeterol MDPI in Adolescent and Adult Patients With Persistent Asthma | Biotech Hunter | Biotech Hunter