A Phase 3 Study of Rilotumumab (AMG 102) With Cisplatin and Capecitabine (CX) as First-line Therapy in Gastric Cancer

PHASE3TerminatedINTERVENTIONAL
Enrollment

34

Participants

Timeline

Start Date

July 31, 2014

Primary Completion Date

June 30, 2015

Study Completion Date

June 30, 2015

Conditions
Gastric Cancer
Interventions
DRUG

Rilotumumab

Rilotumumab is a fully human monoclonal antibody immunoglobulin G, type 2 (IgG2) against human hepatocyte growth factor/scatter factor (HGF/SF) that blocks binding of HGF/SF to its receptor MET, inhibiting HGF/SF/MET-driven activities in cells.

DRUG

Placebo

Placebo

DRUG

Cisplatin

A platinum containing chemo-therapy compound that reacts in vivo, binding to and causing crosslinking of DNA, which ultimately triggers apoptosis (programmed cell death)

DRUG

Capecitabine

A chemo-therapy prodrug that is enzymatically converted to 5-fluorouracil in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.

Trial Locations (25)

464-8681

Research Site, Nagoya

260-8717

Research Site, Chiba

277-8577

Research Site, Kashiwa-shi

791-0280

Research Site, Matsuyama

811-1395

Research Site, Fukuoka

060-8648

Research Site, Sapporo

673-8558

Research Site, Akashi-shi

216-8511

Research Site, Kawasaki-shi

537-8511

Research Site, Osaka

540-0006

Research Site, Osaka

589-8511

Research Site, Osakasayama-shi

565-0871

Research Site, Suita-shi

569-8686

Research Site, Takatsuki-shi

362-0806

Research Site, Kitaadachi-gun

411-8777

Research Site, Suntou-gun

320-0834

Research Site, Utsunomiya

113-8677

Research Site, Bunkyo-ku

410-769

Research Site, Goyang-si, Gyeonggi-do

519-763

Research Site, Hwasun

110-744

Research Site, Seoul

120-752

Research Site, Seoul

135-710

Research Site, Seoul

136-705

Research Site, Seoul

137-701

Research Site, Seoul

138-736

Research Site, Seoul

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY

NCT02137343 - A Phase 3 Study of Rilotumumab (AMG 102) With Cisplatin and Capecitabine (CX) as First-line Therapy in Gastric Cancer | Biotech Hunter | Biotech Hunter