NCT02132026View on ClinicalTrials.gov

Study Investigating the Effect of Drugs Used to Treat Osteoporosis on the Progression of Calcific Aortic Stenosis.

PHASE2CompletedINTERVENTIONAL

Enrollment

152

Participants

Timeline

Start Date

November 12, 2014

Primary Completion Date

November 28, 2019

Study Completion Date

November 28, 2019

Conditions

Calcific Aortic Stenosis

Interventions

DRUG

Denosumab

DRUG

Alendronic Acid

DRUG

Denosumab Placebo

subcutaneous injection of 0.9%Saline at baseline, 6 months, 12 months and 18 months

DRUG

Alendronic Acid Placebo

Inert Capsule containing lactose monohydrate manufactured and labelled by Investigational Supplies Group (ISG) University of Edinburgh.

Trial Locations (1)

EH16 4SA

Clinical Research Facility University of Edinburgh, Edinburgh

All Listed Sponsors

collaborator

British Heart Foundation

OTHER

collaborator

NHS Lothian

OTHER_GOV

lead

University of Edinburgh

OTHER

NCT02132026 - Study Investigating the Effect of Drugs Used to Treat Osteoporosis on the Progression of Calcific Aortic Stenosis. | Biotech Hunter | Biotech Hunter