595
Participants
Start Date
January 6, 2015
Primary Completion Date
February 29, 2020
Study Completion Date
February 29, 2020
Denosumab
Denosumab: 120 mg, s.c. every 3-4 weeks (in cycle 1 additional dose on day 8) until unacceptable toxicity, patient refusal or patient's death (max. 4 years 3 months).
None, standard chemotherapy only
"Possible standard chemotherapies (3 weeks cycles, duration: 4 - 6 cycles):~Cisplatin 75 mg/m2 as an infusion on day 1 Gemcitabine 1250 mg/m2 as an infusion days 1 and 8 or Carboplatin AUC 5 as an infusion on day 1 Gemcitabine 1000 mg/m2 as an infusion days 1 and 8 or Cisplatin 75 mg/m2 as an infusion on day 1 Pemetrexed 500 mg/m2 as an infusion on day 1 or Carboplatin AUC 5 as an infusion on day 1 Pemetrexed 500 mg/m2 as an infusion on day 1"
Onkologiezentrum Berner Oberland, Thun
Clinique et Maternite Sainte Elisabeth, Namur
Kantonsspital Luzern, Lucerne
Kantonsspital Winterthur, Winterthur
Centre Hospitalier Regional De La Citadelle, Liège
Ospedale San Gerardo, Monza
Hôpitale de la Cavale Blanche - CHRU de BREST, Brest
Centre Hospitalier De Beauvais, Beauvais
Hôpital de Villefranche-sur-Saône, Villefranche-sur-Saône
Univ. Klinik für Innere Medizin V, Innsbruck
KH der Elisabethinen Linz, Linz
AKH Wien, Vienna
Otto-Wagner-Spital Department 1, Vienna
Otto-Wagner-Spital Department 2, Vienna
Onze Lieve Vrouw Ziekenhuis, Aalst
University Hosptial Ghent, Ghent
Centre hospitalier universitaire d'Angers, Angers
Centre Hospitalier Annecy, Annecy
GHPSO (Sie de Creil), Creil
Centre Hospitalier Intercommunal Creteil, Créteil
Hospital Center Le Mans, Le Mans
Hôpital du Cluzeau, Limoges
CHBS Lorient, Lorient
Hôpital Louis Pradel, Lyon
Assistance Publique-Hôitaux de Marseille, Marseille
Institut Paoli-Calmettes, Marseille
Centre Hospitalier de Meaux, Meaux
Centre Hospitalier Universitaire Rennes, Rennes
Clinique Mutualiste de l'Estuaire, Saint-Nazaire
CHICAS, Sisteron
ASKLEPIOS - Fachkliniken München - Gauting, München
Pius Hospital, Oldenburg
Cork University Hospital, Cork
Beaumont Hospital, Dublin
Mater Miscordia University Hospital, Dublin
Mater Private Hospital, Dublin
St James's Hospital, Dublin
The Adelaide and Meath Hospital, Dublin
University Hospital Galway, Galway
University Hospital Limerick, Limerick
Hospital Waterford, Waterford
S.G Moscati Hospital, Aversa
IRCCS Azienda Ospedaliera Universitaria San Martino, Genova
San Paolo Hospital, Milan
Maria Sklodowska-Curie Memorial Car, Gliwice
University Clinic Golnik, Golnik
Institute of Oncology Ljubljana, Ljubljana
Hospital General de Alicante, Alicante
Institut Català d'Oncologia - L'Hospitalet, Barcelona
Hospital General Castellón, Castelló
Hospital Universitario Reina Sofia, Córdoba
Complejo Hospitalario de Jaén, Jaén
H. U. Insular Gran Canaria, Las Palmas
Regional Universitario Carlos Haya, Málaga
H Morales Meseguer, Murcia
Hospital Son Espases, Palma de Mallorca
Hospital Arnau Vilanova Valencia, Valencia
Hospital Universitario Miguel Servet, Zaragoza
Kantonsspital Graubünden, Chur
HFR Fribourg, Fribourg
Centre Hospitalier Universitaire Vaudois, Lausanne
Universitätsspital Zürich, Zurich
Aberdeen Royal Infirmary, Aberdeen
Oxford University Hospitals Trust, Oxford
Weston Park Hospital, Sheffield
Hospital De La Santa Creu I Sant Pau, Barcelona
Collaborators (1)
European Organisation for Research and Treatment of Cancer - EORTC
NETWORK
Amgen
INDUSTRY
ETOP IBCSG Partners Foundation
NETWORK