A Trial of Surgery and Fractionated Re-Irradiation for Recurrent Ependymoma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

68

Participants

Timeline

Start Date

May 7, 2014

Primary Completion Date

May 31, 2023

Study Completion Date

May 31, 2028

Conditions
Ependymoma
Interventions
RADIATION

Irradiation

Radiation therapy on this protocol will be based on extent of disease, extent of resection and location. The allowed treatment modalities include conformal or intensity-modulated radiation therapy using photons or proton therapy using double-scattering or spot-scanning methods. The general goal is to initiate radiation therapy within 12 weeks of last surgery performed at the time of recurrence.

PROCEDURE

Surgery

When applicable, surgery will be used to remove metastases. The goal of surgery is to achieve gross total resection of all imaging visible residual tumor.

DRUG

^1^8F-Fluorodeoxyglucose

This is a contrast media that will be given intravenously to aid in tumor visualization.

DRUG

^1^1C-methionine

This is a contrast media that will be given intravenously to aid in tumor visualization.

DEVICE

Photon therapy

Participants will receive one or both: Photon or proton therapy.

DEVICE

Proton therapy

Participants will receive one or both: Photon or proton therapy.

Trial Locations (1)

38105

St. Jude Children's Research Hospital, Memphis

All Listed Sponsors
lead

St. Jude Children's Research Hospital

OTHER

NCT02125786 - A Trial of Surgery and Fractionated Re-Irradiation for Recurrent Ependymoma | Biotech Hunter | Biotech Hunter