NCT02123069 - Vascular Function and Uterine Fibroids | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

April 30, 2013

Primary Completion Date

March 1, 2018

Study Completion Date

March 1, 2018

Conditions

Leiomyoma

Interventions

DEVICE

Brachial artery catheter

A catheter will be placed in the brachial artery by a physician on the study day.

DRUG

Acetylcholine

Acetylcholine will be infused into the brachial catheter while blood flow levels in the forearm are measured. Acetylcholine will be infused at the following doses: 1.0, 2.0, 4.0, and 8.0 ug/100 ml tissue/min for 2 minutes each.

DRUG

Nitroprusside

Nitroprusside will be infused into the brachial catheter while blood flow levels in the forearm are measured. Nitroprusside will be infused at the following doses: 0.25, 0.5, 1.0, and 2.0 ug/100 ml tissue/min for 2 minutes each.

DRUG

Norepinephrine

Norepinephrine will be infused into the brachial catheter while blood flow levels in the forearm are measured. Norepinephrine will be infused at the following doses: 1.0, 2.0, 4.0, and 8.0 ug/100 ml tissue/min for 2 minutes each.

DRUG

Nitroprusside and phenylephrine

A single dose of nitroprusside (100 ug) will be infused through an IV; one minute later, a single dose of phenylephrine (150 ug) will be infused.

Trial Locations (1)

55905

Mayo Clinic, Rochester