NCT02122198View on ClinicalTrials.gov

Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women

NACompletedINTERVENTIONAL
Enrollment

17

Participants

Timeline

Start Date

September 8, 2014

Primary Completion Date

May 30, 2017

Study Completion Date

September 15, 2017

Conditions
Cognitive ImpairmentExecutive DysfunctionEndothelial DysfunctionCardiovascular Disease
Interventions
DRUG

Leuprolide acetate

Lupron 3.75 mg for depot suspension delivered by monthly intramuscular injection for 9 months. First 6 months under parent study (FAME) protocol (NCT01712230); months 6-9 under sub-study.

DRUG

Estradiol

Climara transdermal patch 0.075mg/day applied weekly months 6-9

DRUG

Medroxyprogesterone

Provera 5mg tablets once daily by mouth for 12 days beginning at week 30.

DRUG

Placebo

placebo

Trial Locations (2)

80045

University of Colorado Anschutz Medical Campus, Aurora

80309

University of Colorado Boulder Intermountain Neuroimaging Consortium, Boulder

All Listed Sponsors
lead

University of Colorado, Denver

OTHER

NCT02122198 - Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women | Biotech Hunter | Biotech Hunter