73
Participants
Start Date
May 31, 2014
Primary Completion Date
December 31, 2014
Study Completion Date
March 31, 2015
Chloroquine sulfate
Chloroquine sulfate (NIVAQUINE) - 30 mg/kg for 3 days
DHA-PP
DHA-PIP (Duo-Cotecxin®, DHA 40 mg and PP 320 mg, Zhejiang Holley Nanhu Pharamaceutical Co. Ltd, Jiaxing, Zhejiang province, China): one tablet of DHA-PIP contains 40 mg of dihydroartemisinin (DHA) and 320 mg piperaquine (PIP). It is an oral administration, one dose a day for 3 consecutive days. An adult dose (≥40 kg to 60kg body weight or more than 15 years old) consisted of three doses of 3 tablets over consecutive days (Total dose 9 tablets). The approximate total adult dose was 2-4 mg/kg for DHA and 20mg/kg for PP.
Provincial Hospital, Banlung
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Institut Pasteur, Cambodia
OTHER