Antiemetic Therapy With or Without Olanzapine in Preventing Chemotherapy-Induced Nausea and Vomiting in Patients With Cancer Receiving Highly Emetogenic Chemotherapy

PHASE3CompletedINTERVENTIONAL
Enrollment

401

Participants

Timeline

Start Date

August 20, 2014

Primary Completion Date

April 4, 2015

Study Completion Date

June 15, 2017

Conditions
Hematopoietic/Lymphoid CancerNausea and VomitingUnspecified Adult Solid Tumor, Protocol Specific
Interventions
DRUG

Olanzapine

oral

DRUG

Chemotherapy (cisplatin or cyclophosphamide and doxorubicin)

oral or IV

DRUG

Antiemetic treatment (ondansetron or granisetron or palonosetron; plus dexamethasone; plus fosaprepitant or aprepitant)

oral or IV

OTHER

Placebo

oral

Trial Locations (177)

19713

Christiana Gynecologic Oncology LLC, Newark

Delaware Clinical and Laboratory Physicians PA, Newark

Helen F Graham Cancer Center, Newark

Medical Oncology Hematology Consultants PA, Newark

Regional Hematology and Oncology PA, Newark

19718

Christiana Care Health System-Christiana Hospital, Newark

19801

Christiana Care Health System-Wilmington Hospital, Wilmington

19958

Beebe Medical Center, Lewes

19971

Beebe Health Campus, Rehoboth Beach

19973

Nanticoke Memorial Hospital, Sanford

20007

MedStar Georgetown University Hospital, Washington D.C.

20010

MedStar Washington Hospital Center, Washington D.C.

25701

Edwards Comprehensive Cancer Center, Huntington

27534

Southeastern Medical Oncology Center-Goldsboro, Goldsboro

Wayne Memorial Hospital, Goldsboro

27893

Southeastern Medical Oncology Center-Wilson, Wilson

28328

Southeastern Medical Oncology Center-Clinton, Clinton

28546

Southeastern Medical Oncology Center-Jacksonville, Jacksonville

31701

Phoebe Putney Memorial Hospital, Albany

32117

Florida Hospital Memorial Medical Center, Daytona Beach

40503

Baptist Health Lexington, Lexington

40701

Baptist Health Corbin, Corbin

42701

Hardin Memorial Hospital, Elizabethtown

45420

Dayton NCI Community Oncology Research Program, Dayton

46544

Memorial Regional Cancer Center Day Road, Mishawaka

46601

Memorial Hospital of South Bend, South Bend

48073

William Beaumont Hospital-Royal Oak, Royal Oak

48098

William Beaumont Hospital - Troy, Troy

48336

Botsford Hospital, Farmington

50010

Mary Greeley Medical Center, Ames

McFarland Clinic PC-William R Bliss Cancer Center, Ames

50036

McFarland Clinic PC-Boone, Boone

50129

McFarland Clinic PC-Jefferson, Jefferson

50158

McFarland Clinic PC-Marshalltown, Marshalltown

50266

Methodist West Hospital, West Des Moines

50309

Iowa Methodist Medical Center, Des Moines

Medical Oncology and Hematology Associates-Des Moines, Des Moines

50316

Iowa Lutheran Hospital, Des Moines

50401

Mercy Medical Center - North Iowa, Mason City

50501

McFarland Clinic PC-Trinity Cancer Center, Fort Dodge

51101

Siouxland Regional Cancer Center, Sioux City

51102

Mercy Medical Center-Sioux City, Des Moines

51104

Saint Luke's Regional Medical Center, Sioux City

52402

Physicians' Clinic of Iowa PC, Cedar Rapids

52403

Oncology Associates at Mercy Medical Center, Cedar Rapids

53066

Oconomowoc Memorial Hospital-ProHealth Care Inc, Oconomowoc

53081

Saint Nicholas Hospital, Sheboygan

53149

D N Greenwald Center, Mukwonago

53188

Waukesha Memorial Hospital, Waukesha

53226

Froedtert and the Medical College of Wisconsin, Milwaukee

54017

Westfields Hospital/Cancer Center of Western Wisconsin, New Richmond

54143

Bay Area Medical Center, Marinette

54154

Green Bay Oncology - Oconto Falls, Oconto Falls

54221

Holy Family Memorial Hospital, Manitowoc

54235

Green Bay Oncology - Sturgeon Bay, Sturgeon Bay

54301

Green Bay Oncology at Saint Vincent Hospital, Green Bay

Saint Vincent Hospital, Green Bay

54303

Green Bay Oncology Limited at Saint Mary's Hospital, Green Bay

Saint Mary's Hospital, Green Bay

54401

Marshfield Clinic-Wausau Center, Wausau

54449

Marshfield Clinic, Marshfield

54476

Marshfield Clinic - Weston Center, Weston

54481

Marshfield Clinic Cancer Care at Saint Michael's Hospital, Stevens Point

54494

Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids

54501

Marshfield Clinic at James Beck Cancer Center, Rhinelander

54548

Marshfield Clinic-Minocqua Center, Minocqua

54601

Gundersen Lutheran Medical Center, La Crosse

54701

Marshfield Clinic Cancer Center at Sacred Heart, Eau Claire

54729

Marshfield Clinic-Chippewa Center, Chippewa Falls

54868

Lakeview Medical Center-Marshfield Clinic, Rice Lake

Marshfield Clinic-Rice Lake Center, Rice Lake

54935

Saint Agnes Hospital/Agnesian Cancer Center, Fond du Lac

60123

Advocate Sherman Hospital, Elgin

60426

Ingalls Memorial Hospital, Harvey

61108

OSF Saint Anthony Medical Center, Rockford

61354

Valley Radiation Oncology, Peru

61401

Illinois CancerCare Galesburg, Galesburg

Western Illinois Cancer Treatment Center, Galesburg

61603

Methodist Medical Center of Illinois, Peoria

61615

Illinois CancerCare-Peoria, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61701

Saint Joseph Medical Center, Bloomington

62526

Cancer Care Specialists of Central Illinois, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

62781

Memorial Medical Center, Springfield

62864

Good Samaritan Regional Health Center, Mount Vernon

62902

Memorial Hospital of Carbondale, Carbondale

63109

Saint Louis Cancer and Breast Institute-South City, St Louis

63141

Mercy Hospital Saint Louis, St Louis

64804

Mercy Hospital-Joplin, Joplin

65401

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

Phelps County Regional Medical Center, Rolla

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

80012

Rocky Mountain Cancer Centers-Aurora, Aurora

The Medical Center of Aurora, Aurora

80033

Exempla Lutheran Medical Center, Wheat Ridge

80111

Rocky Mountain Cancer Centers-Greenwood Village, Greenwood Village

80113

Comprehensive Cancer Care and Research Institute of Colorado LLC, Englewood

Swedish Medical Center, Englewood

80120

Rocky Mountain Cancer Centers-Littleton, Littleton

80122

Littleton Adventist Hospital, Littleton

80124

Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree

Sky Ridge Medical Center, Lone Tree

80138

Parker Adventist Hospital, Parker

Rocky Mountain Cancer Centers-Parker, Parker

80210

Porter Adventist Hospital, Denver

80218

Exempla Saint Joseph Hospital, Denver

Presbyterian - Saint Lukes Medical Center - Health One, Denver

Rocky Mountain Cancer Centers-Midtown, Denver

80220

Rocky Mountain Cancer Centers-Rose, Denver

Rose Medical Center, Denver

80228

Rocky Mountain Cancer Centers-Lakewood, Lakewood

Saint Anthony Hospital, Lakewood

80260

Rocky Mountain Cancer Centers-Thornton, Thornton

80301

Boulder Community Hospital, Boulder

80304

Rocky Mountain Cancer Centers-Boulder, Boulder

80401

Mountain Blue Cancer Care Center, Golden

80501

Longmont United Hospital, Longmont

Rocky Mountain Cancer Centers-Longmont, Longmont

80539

McKee Medical Center, Loveland

80631

North Colorado Medical Center, Greeley

80901

Penrose-Saint Francis Healthcare, Colorado Springs

80907

Rocky Mountain Cancer Centers-Penrose, Colorado Springs

Colorado Blood Cancer Institute, Denver

81004

Saint Mary Corwin Medical Center, Pueblo

81008

Rocky Mountain Cancer Centers - Pueblo, Pueblo

81301

Mercy Medical Center, Durango

Southwest Oncology PC, Durango

82001

Cheyenne Regional Medical Center-West, Cheyenne

83301

Saint Luke's Mountain States Tumor Institute-Twin Falls, Twin Falls

83619

Saint Luke's Mountain States Tumor Institute - Fruitland, Fruitland

83642

Saint Luke's Mountain States Tumor Institute - Meridian, Meridian

83686

Saint Luke's Mountain States Tumor Institute - Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

Saint Luke's Mountain States Tumor Institute, Boise

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

92093

UC San Diego Moores Cancer Center, La Jolla

94568

Epic Care-Dublin, Dublin

94608

Bay Area Breast Surgeons Inc, Emeryville

Epic Care Partners in Cancer Care, Emeryville

94609

Alta Bates Summit Medical Center - Summit Campus, Oakland

Bay Area Tumor Institute, Oakland

Hematology and Oncology Associates-Oakland, Oakland

96701

Oncare Hawaii Inc-Pali Momi, ‘Aiea

Pali Momi Medical Center, ‘Aiea

96706

The Cancer Center of Hawaii-Leeward, ‘Ewa Beach

96766

Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue

96813

Oncare Hawaii Inc-POB II, Honolulu

Queen's Medical Center, Honolulu

Straub Clinic and Hospital, Honolulu

University of Hawaii Cancer Center, Honolulu

96817

Kuakini Medical Center, Honolulu

Oncare Hawaii Inc-Kuakini, Honolulu

OnCare Hawaii-Liliha, Honolulu

The Cancer Center of Hawaii-Liliha, Honolulu

96826

Kapiolani Medical Center for Women and Children, Honolulu

96859

Tripler Army Medical Center, Honolulu

98508

Anchorage Associates in Radiation Medicine, Anchorage

98597

Providence Regional Cancer System-Yelm, Yelm

99504

Anchorage Radiation Therapy Center, Anchorage

99508

Alaska Breast Care and Surgery LLC, Anchorage

Alaska Oncology and Hematology LLC, Anchorage

Alaska Regional Hospital, Anchorage

Alaska Women's Cancer Care, Anchorage

Anchorage Oncology Centre, Anchorage

Katmai Oncology Group, Anchorage

Providence Alaska Medical Center, Anchorage

945553

Contra Costa Regional Medical Center, Martinez

06105

Saint Francis Hospital and Medical Center, Hartford

Unknown

Mercy Hospital, Cedar Rapids

02462

Newton-Wellesley Hospital, Newton

02903

Rhode Island Hospital, Providence

02906

Miriam Hospital, Providence

05602

Central Vermont Medical Center, Berlin Corners

05405

University of Vermont College of Medicine, Burlington

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Alliance for Clinical Trials in Oncology

OTHER

NCT02116530 - Antiemetic Therapy With or Without Olanzapine in Preventing Chemotherapy-Induced Nausea and Vomiting in Patients With Cancer Receiving Highly Emetogenic Chemotherapy | Biotech Hunter | Biotech Hunter