Chemotherapy Options for the First Line Chemotherapy in Elderly Patient With Advanced Gastric Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

111

Participants

Timeline

Start Date

February 28, 2014

Primary Completion Date

February 29, 2020

Study Completion Date

February 29, 2020

Conditions
Gastric Cancer
Interventions
DRUG

Capecitabine/cisplatin

Capecitabine/cisplatin (XP) : cisplatin 50mg/m2 (80% dose of 60mg/2m) iv over 15min D1, capecitabine 1000mg/m2 (80% dose of 1250mg/m2) po bid D1-14, q 3wks

DRUG

S-1/cisplatin

S-1/cisplatin (SP) : cisplatin 50mg/m2 (80% dose of 60mg/2m) iv ov 15min D1, S-1 30mg/m2 (80% dose of 40mg/m2) po bid D1-14, q3wks

DRUG

Capecitabine/oxaliplatin

Capecitabine+oxaliplatin (XELOX): oxaliplatin 100mg/m2 (80% dose of 130mg/m2)iv ov 120min D1, capecitabine 800mg/m2 (80% dose of 1000mg/m2) po bid D1-14, q3wks

DRUG

5-fluorouracil/oxaliplatin

5-fluorouracil/oxaliplatin (FOLFOX): oxaliplatin 80mg/m2 (80% dose of 100mg/m2) iv ov 120min, leucovorin 80mg/m2 (80% dose of 100mg/m2) iv ov 120min, 5-fluorouracil 1900mg/m2 (80% dose of 2400mg/m2) iv ov 46h D1, q 2wks

DRUG

Capecitabine

Capecitabine : 1250mg/m2 po bid D1-14 q3wks (if Ccr \<60ml/min, 1000mg/m2 po bid)

DRUG

S-1

S-1 : 40mg/m2 po bid D1-14 q3wks (if Ccr \<60ml/min, 30mg/m2 po bid)

DRUG

5-fluorouracil

5-fluorouracil (FL) : leucovorin 100mg/m2 iv ov 2h, 5-fluorouracil 2400mg/m2 iv ov 46h D1, q2wks

Trial Locations (14)

431-796

Hallym University Sacred Heart Hospital, Anyang

Unknown

Inje University Haeundae Paik Hospital, Busan

Yeongnam University Medical Center, Daegu

Inje University Sanggye Paik Hospital, Seoul

Kangbuk Samsung Hospital, Seoul

The Catholic University of Korea Uijeongbu St. Mary's Hospital, Uijeongbu-si

361-711

Chungbuk National University Hospital, Cheongju-si

702-210

Kyungpook National University Medical Center, Daegu

410-769

National Cancer Center, Goyang

400-713

Gachon University Gil Medical Center, Incheon

614-735

Inje University Pusan Paik Hospital, Pusan

463-707

Seoul National University Bundang Hospital, Seongnam

138-736

Asan Medical Center, Seoul

156-707

SMG-SNU Boramae Medical Center, Seoul

All Listed Sponsors
collaborator

Ministry of Health & Welfare, Korea

OTHER_GOV

collaborator

Korean Cancer Study Group

OTHER

lead

Seoul National University Hospital

OTHER

NCT02114359 - Chemotherapy Options for the First Line Chemotherapy in Elderly Patient With Advanced Gastric Cancer | Biotech Hunter | Biotech Hunter