NCT02105948 - Study to Evaluate Efficacy and Safety of Mepolizumab for Frequently Exacerbating Chronic Obstructive Pulmonary Disease (COPD) Patients | Biotech Hunter

Enrollment

837

Participants

Timeline

Start Date

April 15, 2014

Primary Completion Date

January 17, 2017

Study Completion Date

January 17, 2017

Conditions

Pulmonary Disease, Chronic Obstructive

Interventions

DRUG

Mepolizumab

Humanised IgG antibody (IgG1, kappa) with human heavy and light chain frameworks, provided as a lyophilised cake in sterile vial. Vial to be reconstituted with Sterile Water for Injection, just prior to use.

DRUG

Placebo

Sterile 0.9% sodium chloride solution

Trial Locations (116)

1000

GSK Investigational Site, Brussels

1200

GSK Investigational Site, Brussels

2040

GSK Investigational Site, Kløfta

2107

GSK Investigational Site, Liverpool

3000

GSK Investigational Site, Leuven

3168

GSK Investigational Site, Clayton

3199

GSK Investigational Site, Frankston

4000

GSK Investigational Site, Liège

4870

GSK Investigational Site, Cairns

5041

GSK Investigational Site, Daw Park

5101

GSK Investigational Site, Erpent

6009

GSK Investigational Site, Nedlands

6150

GSK Investigational Site, Murdoch

7027

GSK Investigational Site, Trondheim

8005

GSK Investigational Site, Bodø

8400

GSK Investigational Site, Ostend

10029

GSK Investigational Site, New York

10138

GSK Investigational Site, Tallinn

11527

GSK Investigational Site, Athens

13419

GSK Investigational Site, Tallinn

13619

GSK Investigational Site, Tallinn

13915

GSK Investigational Site, Marseille

14050

GSK Investigational Site, México DF

15213

GSK Investigational Site, Pittsburgh

17027

GSK Investigational Site, Pietra Ligure (SV)

20123

GSK Investigational Site, Milan

24210

GSK Investigational Site, Abingdon

27003

GSK Investigational Site, Lugo

27103

GSK Investigational Site, Winston-Salem

27705

GSK Investigational Site, Durham

28054

GSK Investigational Site, Gastonia

28078

GSK Investigational Site, Huntersville

28207

GSK Investigational Site, Charlotte

28223

GSK Investigational Site, Pozuelo de Alarcón/Madrid

28401

GSK Investigational Site, Wilmington

29010

GSK Investigational Site, Málaga

29303

GSK Investigational Site, Spartanburg

29340

GSK Investigational Site, Gaffney

29615

GSK Investigational Site, Greenville

29640

GSK Investigational Site, Easley

29678

GSK Investigational Site, Seneca

29707

GSK Investigational Site, Fort Mill

34295

GSK Investigational Site, Montpellier

38043

GSK Investigational Site, Grenoble

39003

GSK Investigational Site, Tábor

43125

GSK Investigational Site, Parma

44100

GSK Investigational Site, Guadalajara

44500

GSK Investigational Site, Guadalajara

45070

GSK Investigational Site, Zapopan

45459

GSK Investigational Site, Dayton

51014

GSK Investigational Site, Tartu

55905

GSK Investigational Site, Rochester

56124

GSK Investigational Site, Pisa

56429

GSK Investigational Site, Thessaloniki

57010

GSK Investigational Site, Thessaloniki

63301

GSK Investigational Site, Saint Charles

64000

GSK Investigational Site, Monterrey

64020

GSK Investigational Site, Monterrey

64109

GSK Investigational Site, Bayonne

64718

GSK Investigational Site, Monterrey NL

66000

GSK Investigational Site, Perpignan

68000

GSK Investigational Site, Oaxaca City

69317

GSK Investigational Site, Lyon

74100

GSK Investigational Site, Rethymnon, Crete

80131

GSK Investigational Site, Napoli

92150

GSK Investigational Site, Suresnes

92663

GSK Investigational Site, Newport Beach

97504

GSK Investigational Site, Medford

150003

GSK Investigational Site, Yaroslavl

194354

GSK Investigational Site, Saint Petersburg

194356

GSK Investigational Site, Saint Petersburg

195271

GSK Investigational Site, Saint Petersburg

390039

GSK Investigational Site, Ryazan

454106

GSK Investigational Site, Chelyabinsk

603126

GSK Investigational Site, Nizhny Novgorod

634001

GSK Investigational Site, Tomsk

650000

GSK Investigational Site, Kemerovo

T2N 4Z6

GSK Investigational Site, Calgary

T8H 0N2

GSK Investigational Site, Sherwood Park

R2K 3S8

GSK Investigational Site, Winnipeg

M5T 3A9

GSK Investigational Site, Toronto

N8X 5A6

GSK Investigational Site, Windsor

J8Y 6S8

GSK Investigational Site, Gatineau

H2W1T8

GSK Investigational Site, Montreal

H4J 1C5

GSK Investigational Site, Montreal

J6E 2B4

GSK Investigational Site, Saint-Charles-Borromée

G1V 4G5

GSK Investigational Site, Sainte-Foy

G8T 7A1

GSK Investigational Site, Trois-Rivières

360 17

GSK Investigational Site, Karlovy Vary

140 46

GSK Investigational Site, Prague

415 10

GSK Investigational Site, Teplice

106 76

GSK Investigational Site, Athens

124 62

GSK Investigational Site, Haidari / Athens

06156

GSK Investigational Site, Perugia

07760

GSK Investigational Site, Mexico City

Lima 27

GSK Investigational Site, Lima

Lima 31

GSK Investigational Site, San Martín de Porres

Lima 32

GSK Investigational Site, San Miguel

GSK Investigational Site, Lima

Lima 33

GSK Investigational Site, Santiago de Surco

Lima 18

GSK Investigational Site, Lima

Lima 1

GSK Investigational Site, Lima

Lima 21

GSK Investigational Site, Pueblo Libre

15-044

GSK Investigational Site, Bialystok

82-300

GSK Investigational Site, Elblag

31-024

GSK Investigational Site, Krakow

63-400

GSK Investigational Site, Ostrów Wielkopolski

96-100

GSK Investigational Site, Skierniewice

634 050

GSK Investigational Site, Tomsk

03004

GSK Investigational Site, Alicante

08025

GSK Investigational Site, Barcelona

08036

GSK Investigational Site, Barcelona

08907

GSK Investigational Site, L'Hospitalet de Llobregat

07120

GSK Investigational Site, Palma de Mallorca

SE-221 85

GSK Investigational Site, Lund

SE-141 86

GSK Investigational Site, Stockholm