Evaluation of [18F]MNI-777 PET as a Marker of Tau Pathology in Subjects With Tauopathies Compared to Healthy Subjects

PHASE1CompletedINTERVENTIONAL
Enrollment

16

Participants

Timeline

Start Date

February 28, 2014

Primary Completion Date

August 31, 2016

Study Completion Date

September 30, 2016

Conditions
Alzheimer's Disease (AD)Parkinson's Disease (PD)Chronic Traumatic Encephalopathy (CTE)Progressive Supranuclear Palsy (PSP)Frontal Temporal Dementia (FTD)Pick's DiseaseTauopathies
Interventions
DRUG

[18F]T807 ([18F]MNI-777)

All enrolled subjects will undergo an \[18F\]MNI-777 PET imaging visit. For individuals with AD or CTE, \[18F\]florbetapir imaging may also be performed to serve as a means of correlating disease severity by evaluating the relationship of β-amyloid uptake (measured by \[18F\]florbetapir imaging) and tau protein uptake (measured by \[18F\]MNI-777 PET imaging). For individuals with Parkinsonian symptoms, \[123I\]β-CIT SPECT imaging may be performed to evaluate for a reduction in dopamine transporter uptake.

Trial Locations (1)

06510

Molecular NeuroImaging, LLC, New Haven

Sponsors
All Listed Sponsors
collaborator

Institute for Neurodegenerative Disorders

OTHER

lead

Molecular NeuroImaging

OTHER

NCT02103894 - Evaluation of [18F]MNI-777 PET as a Marker of Tau Pathology in Subjects With Tauopathies Compared to Healthy Subjects | Biotech Hunter | Biotech Hunter