A Study Evaluating the Effects of Lebrikizumab on Airway Eosinophilic Inflammation in Participants With Uncontrolled Asthma

PHASE2CompletedINTERVENTIONAL
Enrollment

64

Participants

Timeline

Start Date

November 6, 2014

Primary Completion Date

October 13, 2016

Study Completion Date

October 13, 2016

Conditions
Asthma
Interventions
DRUG

Lebrikizumab

Lebrikizumab will be administered by SC injection on Day 1, Day 8, Week 4, and Week 8.

DRUG

Placebo

Lebrikizumab matching placebo will be administered by SC injection on Day 1, Day 8, Week 4, and Week 8.

DRUG

Inhaled corticposteroids (ICS)

Participants will continue their ICS controller therapy, as they are receiving prior to screening, throughout the study. Protocol does not specify any particular ICS.

DRUG

Second Asthma Controller Medication

Participants will continue their asthma controller therapy, as they are receiving prior to screening, throughout the study.

Trial Locations (28)

15

Connolly Hospital, Dublin

15213

University of Pittsburgh Medical Center Health System, Pittsburgh

19104

Pen Memory Center, Philadelphia

19140

Temple University Hospital ; Lung Center, Philadelphia

27705

Duke University Medical Center, Durham

33600

Groupe Hospitalier Sud - Hôpital Haut Lévêque, Pessac

34295

Hôpital Arnaud de Villeneuve, Montpellier

52242

University of Iowa Hospitals & Clinics; Internal Medicine, Iowa City

60611

Northwestern University, Chicago

63110

Washington University; Pediatrics, St Louis

77030

Baylor College of Medicine, Houston

90033

LAC-USC Medical Center, Los Angeles

95817

University of California Davis Health System; Division of Pulmonary and Critical Care Medicine, Sacramento

85724-5030

University of Arizona, Tucson

06510

Yale School of Medicine, New Haven

Suite 200

University of Miami School of Medicine - Sylvester at Deerfield, Deerfield Beach

02115

Brigham and Women's Hospital; Pulmonary Division, Boston

27157-1045

Wake Forest University Baptist Medical Center; Gastroenterology & Digestive Health, Winston-Salem

77555-0743

UTMB Pathology Clinical Services, Galveston

T2N 2T9

University of Calgary, Calgary

T6G 2S2

University of Alberta Hospital-SCC/WCM, Edmonton

V5Z 1L8

VGH Research Pavilion, Vancouver

L8N 3Z5

McMaster University Health Sciences Center, Hamilton

221 85

Skånes Universitetssjukhus, Lund, Lund

BT9 7AB

Queen's University Belfast; NICRN Respiratory Research Office, Belfast

LE3 9QP

Glenfield Hospital, Leicester

W2 1NY

St Mary's Hospital, London

M23 9QZ

The Medicines Evaluation Unit, Manchester

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT02099656 - A Study Evaluating the Effects of Lebrikizumab on Airway Eosinophilic Inflammation in Participants With Uncontrolled Asthma | Biotech Hunter | Biotech Hunter