40
Participants
Start Date
October 31, 2014
Primary Completion Date
November 30, 2015
Study Completion Date
November 30, 2015
CPS-immunization
Subjects will be exposed 3 times to bites from 15 NF54 Plasmodium infected mosquitoes during each immunization, while taking chloroquin prophylaxis.
malaria challenge infection, P. falciparum NF135.C10
Subjects will receive bites from 5 Anopheles mosquitoes infected with Plasmodium falciparum NF135.C10 sporozoites.
malaria challenge infection, P. falciparum NF166.C8
Subjects will receive bites from 5 Anopheles mosquitoes infected with Plasmodium falciparum NF166.C8 sporozoites.
malaria challenge infection, P. falciparum NF54
Subjects will receive bites from 5 Anopheles mosquitoes infected with Plasmodium falciparum NF54 sporozoites.
atovaquone/proguanil
All participants will be treated with atovaquone/proguanil when they develop a malaria infection or on day 28 after malaria challenge infection.
Radboud university medical center, Nijmegen
Bill and Melinda Gates Foundation
OTHER
Radboud University Medical Center
OTHER