p53 Suppressor Activation in Recurrent High Grade Serous Ovarian Cancer, a Phase Ib/II Study of Systemic Carboplatin Combination Chemotherapy With or Without APR-246

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

247

Participants

Timeline

Start Date

March 31, 2014

Primary Completion Date

April 30, 2019

Study Completion Date

April 30, 2019

Conditions
Platinum Sensitive Recurrent High-grade Serous Ovarian Cancer With Mutated p53
Interventions
DRUG

APR-246

Intravenous infusion.

DRUG

Carboplatin and Pegylated Liposomal Doxorubicin Hydrochloride (PLD)

Intravenous infusion.

Trial Locations (55)

1000

Institut Jules Bordet, Brussels

2650

Antwerp University Hospital, Antwerp

9000

Medische oncologie, Universitair Ziekenhuis Gent, Ghent

10367

Praxisklinik, Krebsheilkunde für Frauen, Berlin

13353

Charité Campus Virchow-Klinikum, Berlin

14004

Hospital Universitario Reina Sofia, Córdoba

15213

UPMC Hillman Cancer Center, Magee-Womens Hospital, Pittsburgh

19104

The University of Pennsylvania, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

20246

Universitätsklinikum Hamburg-Eppendorf, Hamburg

23298

Massey Cancer Center, Virginia Commonwealth University, Richmond

28033

Centro Oncologico MD Anderson, Madrid

28034

Hospital Universitario Ramón y Cajal, Madrid

28040

Hospital Universitario Fundación Jiménez Díaz, Madrid

28050

Hospital Universitario HM Sanchinarro, Madrid

29010

Hospital Universitario Virgen de la Victoria, Málaga

37232

Vanderbilt University Medical Center, Nashville

44202

Centre Catherine de Sienne, Nantes

46010

Hospital Clinico Universitario de Valencia, Valencia

48201

Barbara Ann Karmanos Cancer Institute, Detroit

50009

Hospital Clínico Universitario Lozano Blesa, Zaragoza

60637

University of Chicago, Chicago

67065

Centre Paul Strass, Strasbourg

69373

Centre Léon Bérard, Lyon

69495

Centre Hospitalier Lyon Sud, Lyon

75005

Institut Curie, Paris

75012

Hôpital des Diaconesses (Site Reuilly), Paris

75390

Parkland, UT Southwestern Medical Center, Dallas

University of Texas Southwestern Medical Center, Dallas

77030

The University of Texas MD Anderson Cancer Center, Houston

89075

Universitätsfrauenklinik Ulm, Ulm

90095

UCLA, Los Angeles

94805

Institut Gustave Roussy, Villejuif

97239

Oregon Health & Science University, Portland

98104

Swedish Cancer Institute, Seattle

02114

Massachusetts General Hospital, Boston

02215

Dana Farber Cancer Institute, Boston

B-1200

Cliniques Universitaires Saint Luc, Brussels

B-3000

Leuven University Hospitals, Leuven

01307

Universitätsklinikum Carl Gustav Carus, Dresden

1105 AZ

Academisch Medisch Centrum, Amsterdam

9700 RB

Universitair Medisch Centrum Groningen, Groningen

2300 RC

Leids Universitair Medisch Centrum, Leiden

6229 HX

Academisch Ziekenhuis Maastricht, Maastricht

08916

Institut Català d'Oncologia, Hospital Germans Trias i Pujol, Badalona

08035

Hospital Vall d'Hebron, Barcelona

01009

Hospital Universitario Araba, Vitoria-Gasteiz

SE-171 76

Karolinska University Hospital, Stockholm

BS2 8ED

Bristol Haematology & Oncology Centre, University Hospitals Bristol, Bristol

CB2 0QQ

Cambridge Cancer Trials Centre, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge

EH4 2XR

Edinburgh Cancer Research Centre, The University of Edinburgh, Edinburgh

CH63 4JY

The Clatterbridge Cancer Center NHS Foundation Trust, Liverpool

SM2 5PT

The Royal Marsden NHS Foundation Trust, London

W12 0NN

Imperial College London, Hammersmith Hospital Campus, London

M20 4BX

The Christie NHS Foundation Trust, Manchester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Aprea Therapeutics

INDUSTRY