OnabotulinumtoxinA for the Treatment of Urinary Incontinence Due to Overactive Bladder in Pediatric Patients (12 to 17)

PHASE3TerminatedINTERVENTIONAL
Enrollment

56

Participants

Timeline

Start Date

May 23, 2014

Primary Completion Date

February 10, 2022

Study Completion Date

February 10, 2022

Conditions
Urinary IncontinenceUrinary BladderOveractive
Interventions
BIOLOGICAL

BOTOX®

Each vial of BOTOX (Botulinum Toxin Type A) purified neurotoxin complex, formulation No. 9060X contains 100 U of Clostridium botulinum toxin Type A, 0.5 mg albumin (human), and 0.9 mg sodium chloride in a sterile, vacuum-dried form without a preservative. The study medication was to be reconstituted with 0.9% sodium chloride (preservative-free). The 10 mL of study drug was to be administered as 20 injections each of 0.5 mL. Under direct cystoscopic visualization, injections were to be distributed evenly across the detrusor wall and spaced approximately 1 cm apart. To avoid injecting the trigone, the injections were to be at least 1 cm above the trigone. The injection needle was to be inserted approximately 2 mm into the detrusor for each injection.

Trial Locations (39)

2031

Sydney Children's Hospital /ID# 237191, Randwick

2145

The Children's Hospital at Westmead /ID# 234337, Sydney

2650

Universitair Ziekenhuis Antwerpen /ID# 237997, Edegem

3000

Universitair Ziekenhuis Leuven /ID# 237218, Leuven

3168

Monash Children's Hospital /ID# 234388, Clayton

6001

St Georges Hospital /ID# 235316, Port Elizabeth

9000

UZ Gent /ID# 237588, Ghent

23538

Universitaetsklinikum Schleswig-Holstein Campus Luebeck /ID# 234288, Lübeck

27612

Associated Urologist of North Carolina /ID# 235437, Raleigh

32806

Orlando Health-Arnold Palmer Hospital for Children Pediatric Urology /ID# 235283, Orlando

33076

Duplicate_CHU Bordeaux-Hopital Pellegrin /ID# 237392, Bordeaux

33617

Evangelisches Krankenhaus Bielefeld /ID# 235234, Bielefeld

53226

Children's Hospital Wisconsin - Milwaukee Campus /ID# 237544, Milwaukee

72202

Arkansas Children's Hospital /ID# 237787, Little Rock

76104

Cook Children's Med. Center /ID# 237539, Fort Worth

79312

Urologische Gemeinschaftspraxis /ID# 234978, Emmendingen

80045

Children's Hospital Colorado /ID# 237621, Aurora

80138

AOU Universita degli Studi della Campania Luigi Vanvitelli /ID# 237308, Napoli

87042

Hôpital de la Mère et de l'Enfant /ID# 235227, Limoges

99503-3902

Alaska Urological Institute /ID# 238189, Anchorage

06510-3206

Yale New Haven Hospital - Yale School of Medicine /ID# 238222, New Haven

T3B 6A8

Alberta Children's Hospital /ID# 237510, Calgary

N6A 5W9

London Health Sciences Center /ID# 234304, London

J1H 5N4

CHUS - Hopital Fleurimont /ID# 237668, Sherbrooke

779 00

Fakultni nemocnice Olomouc /ID# 237577, Olomouc

06200

Hôpitaux Pédiatriques de Nice CHU-LENVAL /ID# 235278, Nice

6525 GA

Radboud Universitair Medisch Centrum /ID# 237043, Nijmegen

6229 HX

Maastricht Universitair Medisch Centrum /ID# 237678, Maastricht

0372

Oslo University Hospital /ID# 234434, Oslo

50-556

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu /ID# 238166, Wroclaw

61-512

Specjalistyczny Gabinet Lekarski /ID# 235257, Poznan

02-798

Medical Concierge Centrum Medyczne /ID# 235200, Warsaw

M13 9WL

Manchester University NHS Foundation Trust /ID# 234380, Manchester

NR4 7UY

Norfolk and Norwich University Hospitals NHS Foundation Trust /ID# 234819, Norwich

G12 0XH

NHS Greater Glasgow and Clyde /ID# 237430, Glasgow

AB15 6RE

NHS Grampian /ID# 237379, Aberdeen

L12 2AP

Alder Hey Children's NHS Foundation Trust /ID# 237279, Liverpool

RG1 5AN

Royal Berkshire NHS Foundation Trust /ID# 236915, Reading

S10 2TH

Sheffield Children's NHS Foundation Trust /ID# 237854, Sheffield

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Allergan

INDUSTRY