Efficacy and Safety of a Single Low-dose Primaquine for the Clearance of Gametocytes

PHASE4CompletedINTERVENTIONAL
Enrollment

220

Participants

Timeline

Start Date

July 31, 2014

Primary Completion Date

October 31, 2014

Study Completion Date

November 30, 2014

Conditions
Plasmodium Falciparum
Interventions
DRUG

Primaquine (For artemether-lumefantrine+primaquine arm)

A 0.25 mg/kg single-dose primaquine will be administered concomitantly with the first dose of artemether-lumefantrine in all patients randomized into the artemether-lumefantrine+primaquine arm.

DRUG

Placebo (For artemether-lumefantrine arm)

Volume of normal saline mixed with coloured fruit juice measured based on weight bands will be given orally concomitantly with first dose of artemether-lumefantrine.

Trial Locations (1)

65001

Muhimbili University of Health and Allied Sciences, Dar es Salaam

All Listed Sponsors
collaborator

Karolinska Institutet

OTHER

lead

Muhimbili University of Health and Allied Sciences

OTHER

NCT02090036 - Efficacy and Safety of a Single Low-dose Primaquine for the Clearance of Gametocytes | Biotech Hunter | Biotech Hunter