Study of LEE011 With Fulvestrant and BYL719 or BKM120 in Advanced Breast Cancer

LEE011: supplied as capsules of dosage strength of 50 mg or 200 mg. The capsules will be differentiated through different sizes

BYL719: supplied as tablets of dosage strength of 10 mg, 50 mg or 200 mg. Tablets will be differentiated through different sizes and/or colors.

Fulvestrant will be supplied according to local practice and regulation. Fulvestrant is a commercially available product, comes in 500 mg dose and is an injection for intramuscular (i.m.) administration.

BKM120: supplied as 10 mg or 50 mg capsules. The capsules will be differentiated through different sizes.