Effect of Different Strategies for Titrating a High MAP on Microcirculation

Norepinephrine infusion to titrate MAP to usual level

Patients received 500 ml crystalloid for fluid challenge within 20 minutes, then a PLR test was performed to predict fluid responsiveness. If the patient was fluid responsive, more 500 ml crystalloids were given until fluid nonresponsive. If the MAP still not achieved the target value, NE was increased to achieve the target one.