NCT02080195 - Nonmyeloablative Conditioning and Transplantation for Patients With Refractory Systemic Lupus Erythematosus (SLE) | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

September 13, 2016

Primary Completion Date

March 28, 2017

Study Completion Date

March 29, 2017

Conditions

Lupus ErythematosusGraft-versus-host Disease

Interventions

DRUG

Cyclophosphamide

14.5 mg/kg/day on Days -6 and -5. 50 mg/kg/day on Days 3 and 4.

DRUG

Fludarabine

30 mg/m\^2/day on Days -6 through -2.

DRUG

Tacrolimus

Starting on Day 5. Dose will be adjusted according to blood levels.

DRUG

Mycophenolate Mofetil

15 mg/kg three times per day from Day 5 to Day 35.

DRUG

Rabbit antithymocyte globulin

0.5 mg/kg on Day -9. 2 mg/kg/day on Days -8 and -7.

RADIATION

Total body irradiation

200 centigray on Day -1.

BIOLOGICAL

Allogeneic bone marrow transplant

Infusion on Day 0.

Trial Locations (1)

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore