Soy Isoflavone in Combination With Radiation Therapy and Cisplatin in SCC of the Head and Neck

Patients will receive genistein 150 mg daily for the duration of radiation treatment. If a patient is experiencing significant side effects attributable to genistein, the treating physician has the option to reduce genistein to 150 mg every other day.

All patients will undergo computed tomography (CT) simulation with intravenous (IV) contrast unless medical contraindications to IV contrast exist. Gross disease will be treated to 70 Gy in 2 Gy/day.

Cisplatin chemotherapy 100 mg/m² on days 1, 22, and 43 of radiation treatment.