Study of Orally Administered AG-120 in Subjects With Advanced Hematologic Malignancies With an IDH1 Mutation

PHASE1RecruitingINTERVENTIONAL
Enrollment

291

Participants

Timeline

Start Date

March 1, 2014

Primary Completion Date

March 31, 2026

Study Completion Date

March 31, 2026

Conditions
Relapsed or Refractory Acute Myeloid Leukemia (AML)Untreated AMLOther IDH1-mutated Positive Hematologic MalignanciesMyelodysplastic Syndromes
Interventions
DRUG

AG-120

AG-120 administered continuously as a single agent dosed orally every day of a 28-day cycle. Subjects may continue treatment with AG-120 until disease progression, development of other unacceptable toxicity or hematopoietic stem cell transplant.

Trial Locations (30)

10021

ACTIVE_NOT_RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10065

TERMINATED

Cornell Cancer Center, New York

21287

ACTIVE_NOT_RECRUITING

John Hopkins Cancer Center, Baltimore

27705

TERMINATED

Duke Cancer Center, Durham

29425

RECRUITING

Medical University of South Carolina, Charleston

30322

ACTIVE_NOT_RECRUITING

Emory University, Atlanta

32224

TERMINATED

Mayo Clinic-Jacksonville, Jacksonville

33136

TERMINATED

University of Miami, Miami

33600

RECRUITING

Hopital Haut-Leveque, Pessac

33612

ACTIVE_NOT_RECRUITING

Moffit Cancer Center, Tampa

35294

ACTIVE_NOT_RECRUITING

University of Alabama at Birmingham, Birmingham

37203

TERMINATED

Sarah Cannon Research Institute, Nashville

43210

TERMINATED

Ohio State University, Columbus

44124

WITHDRAWN

Cleveland Clinic, Cleveland

48201

TERMINATED

Karmanos Cancer Center, Detroit

60611

TERMINATED

Northwestern University Medical Hospital, Chicago

63110

TERMINATED

Washington University, St Louis

69310

RECRUITING

Central Lyon Sud, Pierre-Bénite

75390

RECRUITING

UT Southwestern Medical Center, Dallas

77030

RECRUITING

MD Anderson Cancer Center, Houston

80045

TERMINATED

University of Colorado Denver, Aurora

85259

TERMINATED

Mayo Clinic-AZ, Phoenix

90095

TERMINATED

University of California-Los Angeles, Los Angeles

91010

ACTIVE_NOT_RECRUITING

City of Hope, Duarte

94143

TERMINATED

University of California-San Francisco, San Francisco

94800

RECRUITING

Institute Gustave Roussly (IGR), Villejuif

97239

TERMINATED

Oregon Health and Science University, Portland

02214

TERMINATED

Massachusetts General Hospital, Boston

02215

TERMINATED

Dana Farber Cancer Institute, Boston

Unknown

TERMINATED

Hopital La Timone, Marseille

All Listed Sponsors
lead

Institut de Recherches Internationales Servier

OTHER