A Study of the Efficacy and Safety of Alteplase in Participants With Mild Stroke

PHASE3TerminatedINTERVENTIONAL
Enrollment

313

Participants

Timeline

Start Date

May 31, 2014

Primary Completion Date

March 22, 2017

Study Completion Date

March 22, 2017

Conditions
Stroke
Interventions
DRUG

Alteplase

Single dose of alteplase will be administered at 0.9 milligrams per kilogram (mg/kg) IV (maximal dose of 90 mg).

DRUG

Alteplase Placebo

Single dose of alteplase placebo will be administered as IV injection.

DRUG

Aspirin

Single dose of aspirin will be administered at 325 mg orally.

DRUG

Aspirin Placebo

Single dose of aspirin placebo will be administered orally.

Trial Locations (88)

10029

Ichan School of Medicine at Mount Sinai, New York

10032

Columbia University Medical Center, New York

11203

SUNY Downstate Medical Center., Brooklyn

11220

Lutheran Medical Center, Brooklyn

14203

Buffalo General Medical Center, Buffalo

15213

University of Pittsburgh Medical Center, Pittsburgh

15219

University of Pittsburgh Cancer Institute, Pittsburgh

17033

Penn State Hershey Medical Center, Hershey

17403

York Hospital, York

18105

Lehigh Valley Hospital, Allentown

19107

Thomas Jefferson University, Philadelphia

19140

Temple University Hospital, Philadelphia

19141

Albert Einstein Healthcare Network, Philadelphia

21133

Northwest Hospital Center, Randallstown

21215

Sinai Hospital of Baltimore, Baltimore

22031

Inova Fairfax Hospital, Fairfax

26506

West Virginia University Hospital, Morgantown

27157

Wake Forest Baptist Medical Center, Winston-Salem

27401

Guilford Neurologic Associates, Greensboro

27514

University of North Carolina At Chapel Hill, Chapel Hill

29118

The Neurology And Pain Clinic, Orangeburg

29425

Medical University of South Carolina; MSC 300, Charleston

33136

University of Miami Miller School of Medicine; Clinical Reseach Building, Miami

33308

Neurologic Consultants, P.A., Fort Lauderdale

34209

Nova Clinical Research, LLC, Bradenton

37404

Chattanooga Center for Neurologic Research, Chattanooga

37920

University of Tennessee Medical Center, Knoxville

39216

University of Mississippi Medical Center, Jackson

40536

University of Kentucky, Lexington

41017

"St. Elizabeth Edgewood; Cancer Care Center for Account St. Elizabeth Edgewood", Edgewood

41042

St. Elizabeth Florence, Florence

41075

St. Elizabeth Fort Thomas, Fort Thomas

42791

University of Louisville, Elizabethtown

43214

Riverside Methodist Hospital, Columbus

43614

University of Toledo Medical Center, Toledo

44109

Case Western Reserve University, Cleveland

44195

Cleveland Clinic, Cleveland

44307

Akron General Medical Center, Akron

45014

Fairfield Hospital, Fairfield

45211

West Hospital, Cincinnati

45219

The Christ Hospital, Cincinnati

45236

Jewish Hospital, Cincinnati

45255

Anderson Hospital, Cincinnati

45409

Wright State University, Dayton

46845

Parkview Research Center, Fort Wayne

48073

Beaumont Hospital, Royal Oak

48201

Detroit Receiving Hospital, Detroit

48341

St Joesph Mercy Hospital Oakland, Pontiac

48909

Sparrow Health System, Lansing

53792

University of Wisconsin, Madison

54601

Gunderson Health System, La Crosse

55422

The Minneapolis Clinic of Neurology, Golden Valley

60007

Alexian Brothers Neuroscience Institute, Elk Grove Village

60611

Northwestern University, Chicago

63128

Washington University, St Louis

65212

University of Missouri Health Care, Columbia

66160

University of Kansas Medical Center, Kansas City

77030

Methodist Neurological Institute, Houston

University Of Texas Health Science Center Houston, Houston

78229

University Hospital San Antonio, San Antonio

78550

Valley Baptist Medical Center, Harlingen

79430

Texas Tech Univ Health Sci Ctr, Lubbock

80113

Colorado Neurological Institute, Englewood

80524

Poudre Valley Hospital, Fort Collins

80538

Medical Center of The Rockies, Loveland

84108

University Of Utah, Salt Lake City

85006

Banner Good Samaritan Medical Center, Phoenix

89502

Renown Health; Renown Institute for Neurosciences, Reno

90048

Cedars Sinai Medical Center, Los Angeles

90404

University of California Los Angeles, Santa Monica

92093

University of California San Diego, La Jolla

92658

Hoag Memorial Hospital, Newport Beach

92835

St. Jude Medical Center, Fullerton

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent's Medical Center, Portland

98122

Swedish Medical Center, Seattle

35294-3300

University of Alabama at Birmingham, Birmingham

85724-5030

University of Arizona, Tucson

06810

Associated Neurologists PC, Danbury

06824

Associated Neurologists of Southern CT PC, Fairfield

06102

Hartford Hospital, Hartford

19718-0002

Christiana Care Health Services; Sponsor Programs Ammon Education Center, Newark

60612-3244

Rush University Medical Center, Chicago

07601

Hackensack University Medical Center, Hackensack

07902

Overlook Hospital, Summit

08755

Shore Neurology, Toms River

45203-0542

University of Cincinnati, Cincinnati

29203-7606

University of South Carolina School of Medicine, Columbia

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Genentech, Inc.

INDUSTRY

NCT02072226 - A Study of the Efficacy and Safety of Alteplase in Participants With Mild Stroke | Biotech Hunter | Biotech Hunter