A Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Anti-Cancer Activity of Trametinib in Combination With Palbociclib in Subjects With Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

28

Participants

Timeline

Start Date

April 22, 2014

Primary Completion Date

June 23, 2016

Study Completion Date

June 23, 2016

Conditions
Cancer
Interventions
DRUG

Trametinib

Trametinib is available as a 0.5 mg yellow oval tablet or as a 2.0 mg pink round tablet.

DRUG

Palbociclib

Palbociclib is available as a 75 mg (size 2 sunset yellow) or 100 mg (size 1 sunset yellow/caramel) or 125 mg (size 0 caramel) capsule.

Trial Locations (3)

37232

GSK Investigational Site, Nashville

02114

GSK Investigational Site, Boston

77030-4009

GSK Investigational Site, Houston

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Pfizer

INDUSTRY

lead

GlaxoSmithKline

INDUSTRY

NCT02065063 - A Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Anti-Cancer Activity of Trametinib in Combination With Palbociclib in Subjects With Solid Tumors | Biotech Hunter | Biotech Hunter