Study of Efficacy and Safety, Tolerability and Pharmacokinetics of Telbivudine in Children and Adolescents With Compensated Chronic Hepatitis B Virus Infection

PHASE3TerminatedINTERVENTIONAL
Enrollment

53

Participants

Timeline

Start Date

October 31, 2014

Primary Completion Date

January 9, 2019

Study Completion Date

January 9, 2019

Conditions
Chronic Hepatitis B
Interventions
DRUG

Telbivudine

Patients of any age and weight\< 30kg: telbivudine oral solution (20 mg/mL): 20 mg/kg up to 600 mg q.d corresponding to weight (kg) x1mL, p.o. once daily Patients \< 12 years old and weight≥ 30kg: telbivudine oral solution (20mg/mL), 600 mg/day corresponding to 30 mL p.o. once daily Patients ≥ 12 years old and weight ≥ 30kg: telbivudine film-coated tablet, 600 mg/day, corresponding to 1 tablet p.o. once daily

DRUG

Placebo

Patients of any age and weight \< 30kg: placebo oral solution corresponding to weight (kg) x1mL, p.o. once daily Patients \< 12 years old and weight ≥ 30kg: placebo oral solution corresponding to 30 mL p.o. once daily Patients ≥ 12 years old and weight ≥ 30kg: placebo tablet, corresponding to 1 tablet p.o. once daily

Trial Locations (29)

1407

Novartis Investigative Site, Sofia

1700

Novartis Investigative Site, Sofia

5800

Novartis Investigative Site, Pleven

9010

Novartis Investigative Site, Varna

12462

Novartis Investigative Site, Athens

16100

Novartis Investigative Site, Nazareth

21000

Novartis Investigative Site, Diyarbakır

21029

Novartis Investigative Site, Vinnytsia

22100

Novartis Investigative Site, Nahariya

23119

Novartis Investigative Site, Elâzığ

26040

Novartis Investigative Site, Eskişehir

33343

Novartis Investigative Site, Mersin

49006

Novartis Investigative Site, Dnipropetrovsk

65031

Novartis Investigative Site, Odesa

91031

Novartis Investigative Site, Jerusalem

91120

Novartis Investigative Site, Jerusalem

200515

Novartis Investigative Site, Craiova

300011

Novartis Investigative Site, Timișoara

400177

Novartis Investigative Site, Cluj-Napoca

700309

Novartis Investigative Site, Iași

115 27

Novartis Investigative Site, Goudi-Athens

011743

Novartis Investigative Site, Bucharest

021105

Novartis Investigative Site, Bucharest

022328

Novartis Investigative Site, Bucharest

05505

Novartis Investigative Site, Seoul

06100

Novartis Investigative Site, Ankara

07070

Novartis Investigative Site, Antalya

Unknown

Novartis Investigative Site, Kiev

04119

Novartis Investigative Site, Kyiv

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY