18
Participants
Start Date
July 21, 2014
Primary Completion Date
September 12, 2018
Study Completion Date
April 9, 2019
PI3K inhibitor BKM120
Will be supplied to each patient on the first day of each cycle. It will subsequently be self administered by the patient themselves daily on days 1-28 of every 28 day cycle
rituximab
Given IV (intervenously) on days 2, 8, 15, and 22 of cycle 1, and subsequently on day 1 of cycles 3, 5, 7, 9, and 11.
Pharmacodynamics
Pharmacodynamic samples from peripheral blood (for those with peripheral blood involvement) and bone marrow aspirate (for all patients) are drawn at baseline.
Correlative studies
Patients will undergo correlative studies to include bone marrow biopsy at study enrollment, and at the time of complete remission. In addition, patients with peripheral blood involvement at enrollment will have peripheral blood drawn for all planned research correlates.
Emory University, Atlanta
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center, Columbus
Collaborators (1)
Novartis
INDUSTRY
Kami Maddocks, MD
OTHER