30
Participants
Start Date
January 31, 2014
Primary Completion Date
June 30, 2015
Study Completion Date
June 30, 2015
Mexiletine
"Mexiletine is a lidocaine-derivate and belongs to the class of 1B antiarrhythmic agents (Vaughan-Williams Classification of Antiarrhytmica). Class I antiarrhythmics have membrane-stabilizing properties. Drugs in this class work by interfering with the fast influx of sodium by inhibition of sodium ionchannels during the fast depolarization phase, thereby decreasing the maximal voltage and upshoot phase of the action potential.~Mexiletine study-medication will be purchased from Stabilimento Chimico Farmaceutico Militare, Firenze, Italy."
Placebo
Placebo tablets do not contain any active medicinal component.
Departments of Neurology, Radboud University Nijmegen Medical Centre, the Netherlands, Nijmegen
ZonMw: The Netherlands Organisation for Health Research and Development
OTHER
Radboud University Medical Center
OTHER