Biomarker-Integrated Approach of Targeted Therapy for Lung Cancer Elimination Plus External Beam Radiation Therapy (BATTLE-XRT)

"Phase I: Starting dose of Onartuzumab 10 mg/kg by vein on Day 1 of each 3 week cycle.~Phase II: Maximum tolerated dose from Phase I."

Phase I and II: 150 mg by mouth every day throughout radiation, except for chemotherapy day.

Phase I and II: 45 mg/m2 by vein once a week throughout radiation for 7 weeks.

Phase I and II: AUC 2 by vein once a week throughout radiation for 7 weeks.

Phase I and II: Radiation therapy at 66 Gy in 33 fractions delivered 5 days a week for 7 weeks, or proton therapy delivered at biological equivalent to 66 Gy (RBE) (RBE = 1.1) in 33 fractions 5 days a week for 7 weeks.