53
Participants
Start Date
February 28, 2014
Primary Completion Date
January 31, 2017
Study Completion Date
April 30, 2017
Capecitabine
Given PO
Fluorouracil
Given IV
Laboratory Biomarker Analysis
Correlative studies
Leucovorin Calcium
Given IV
Trametinib
Given PO
Columbia University/Herbert Irving Cancer Center, New York
University of Rochester, Rochester
Southwest VA Regional Cancer Center, Norton
Southeast Clinical Oncology Research (SCOR) Consortium NCORP, Winston-Salem
Southeastern Medical Oncology Center-Goldsboro, Goldsboro
Wayne Memorial Hospital, Goldsboro
Southeastern Medical Oncology Center-Wilson, Wilson
Southeastern Medical Oncology Center-Clinton, Clinton
Southeastern Medical Oncology Center-Jacksonville, Jacksonville
Iredell Memorial Hospital, Statesville
Cancer Care of Western North Carolina, Asheville
Mission Hospital-Memorial Campus, Asheville
Asheville Hematology-Oncology Associates, Asheville
Spartanburg Medical Center, Spartanburg
Greenville Health System Cancer Institute-Spartanburg, Spartanburg
Roper Hospital, Charleston
Charleston Hematology Oncology Associates-Roper, Charleston
Lowcountry Hematology Oncology PA-North Charleston, Charleston
Charleston Hematology Oncology Associates PA-St. Francis, Charleston
Lowcountry Hematology Oncology PA-West Ashley, Charleston
Lowcountry Hematology Oncology PA-Mount Pleasant, Mt. Pleasant
Saint Francis Hospital, Greenville
Greenville Health System Cancer Institute-Andrews, Greenville
Greenville Health System Cancer Institute-Butternut, Greenville
Greenville Health System Cancer Institute-Faris, Greenville
Greenville Memorial Hospital, Greenville
Greenville Health System Cancer Institute-Eastside, Greenville
Greenville Health System Cancer Institute-Easley, Easley
Greenville Health System Cancer Institute-Greer, Greer
Gibbs Cancer Center-Pelham, Greer
Greenville Health System Cancer Institute-Seneca, Seneca
University of Florida, Gainesville
Moffitt Cancer Center, Tampa
Wellmont Medical Associates Oncology and Hematology-Johnson City, Johnson City
Wellmont Bristol Regional Medical Center, Bristol
Wellmont Holston Valley Hospital and Medical Center, Kingsport
Wellmont Medical Associates Oncology and Hematology-Kingsport, Kingsport
Oncology Hematology Care Inc-Crestview, Crestview Hills
Delaware Health Center-Grady Cancer Center, Delaware
Delaware Radiation Oncology, Delaware
Grady Memorial Hospital, Delaware
Knox Community Hospital, Mount Vernon
Licking Memorial Hospital, Newark
Newark Radiation Oncology, Newark
Saint Ann's Hospital, Westerville
Fairfield Medical Center, Lancaster
Ohio State University Comprehensive Cancer Center, Columbus
Columbus Oncology and Hematology Associates Inc, Columbus
Riverside Methodist Hospital, Columbus
Columbus NCI Community Oncology Research Program, Columbus
Grant Medical Center, Columbus
The Mark H Zangmeister Center, Columbus
Mount Carmel Health Center West, Columbus
Doctors Hospital, Columbus
Genesis Healthcare System Cancer Care Center, Zanesville
Oncology Hematology Care Inc-Healthplex, Fairfield
Oncology Hematology Care Inc-Eden Park, Cincinnati
Oncology Hematology Care Inc-Mercy West, Cincinnati
Oncology Hematology Care Inc - Anderson, Cincinnati
Oncology Hematology Care Inc-Kenwood, Cincinnati
Oncology Hematology Care Inc-Blue Ash, Cincinnati
Wayne Hospital, Greenville
Upper Valley Medical Center, Troy
Good Samaritan Hospital - Dayton, Dayton
Miami Valley Hospital, Dayton
Samaritan North Health Center, Dayton
Dayton NCI Community Oncology Research Program, Dayton
Kettering Medical Center, Kettering
Springfield Regional Medical Center, Springfield
Adena Regional Medical Center, Chillicothe
Southern Ohio Medical Center, Portsmouth
Strecker Cancer Center-Belpre, Belpre
Marietta Memorial Hospital, Marietta
Blanchard Valley Hospital, Findlay
Reid Health, Richmond
Lake Huron Medical Center, Port Huron
Saint John Macomb-Oakland Hospital, Warren
Michigan Cancer Research Consortium NCORP, Ann Arbor
University of Michigan Comprehensive Cancer Center, Ann Arbor
Beaumont Hospital-Dearborn, Dearborn
Saint Mary Mercy Hospital, Livonia
Wayne State University/Karmanos Cancer Institute, Detroit
Saint John Hospital and Medical Center, Detroit
Weisberg Cancer Treatment Center, Farmington Hills
Saint Joseph Mercy Oakland, Pontiac
Hurley Medical Center, Flint
Genesys Hurley Cancer Institute, Flint
Saint Mary's of Michigan, Saginaw
Sparrow Hospital, Lansing
Bronson Battle Creek, Battle Creek
Lakeland Hospital, Saint Joseph
Marie Yeager Cancer Center, Saint Joseph
Lakeland Community Hospital, Niles
Allegiance Health, Jackson
Mercy Health Mercy Campus, Muskegon
Mercy Health Saint Mary's, Grand Rapids
Spectrum Health at Butterworth Campus, Grand Rapids
Spectrum Health Reed City Hospital, Reed City
Munson Medical Center, Traverse City
Billings Clinic Cancer Center, Billings
Montana Cancer Consortium NCORP, Billings
Saint Vincent Healthcare, Billings
Benefis Healthcare- Sletten Cancer Institute, Great Falls
Saint Peter's Community Hospital, Helena
Saint James Community Hospital and Cancer Treatment Center, Butte
Bozeman Deaconess Hospital, Bozeman
Saint Patrick Hospital - Community Hospital, Missoula
Community Medical Hospital, Missoula
Kalispell Regional Medical Center, Kalispell
Loyola University Medical Center, Maywood
Illinois CancerCare-Ottawa Clinic, Ottawa
Radiation Oncology of Northern Illinois, Ottawa
Illinois CancerCare-Peru, Peru
Valley Radiation Oncology, Peru
Illinois CancerCare-Princeton, Princeton
Illinois CancerCare-Galesburg, Galesburg
Western Illinois Cancer Treatment Center, Galesburg
Illinois CancerCare-Kewanee Clinic, Kewanee
Illinois CancerCare-Macomb, Macomb
Illinois CancerCare-Canton, Canton
Illinois CancerCare-Eureka, Eureka
Illinois CancerCare-Pekin, Pekin
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center, Pekin
Methodist Medical Center of Illinois, Peoria
Illinois CancerCare-Peoria, Peoria
OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria
OSF Saint Francis Medical Center, Peoria
Saint Joseph Medical Center, Bloomington
Illinois CancerCare-Bloomington, Bloomington
Illinois CancerCare-Carthage, Carthage
Crossroads Cancer Center, Effingham
Cancer Care Center of Decatur, Decatur
Decatur Memorial Hospital, Decatur
Central Illinois Hematology Oncology Center, Springfield
Southern Illinois University School of Medicine, Springfield
Springfield Clinic, Springfield
Memorial Medical Center, Springfield
Centralia Oncology Clinic, Centralia
Good Samaritan Regional Health Center, Mount Vernon
Memorial Hospital of Carbondale, Carbondale
Missouri Baptist Sullivan Hospital, Sullivan
Saint Louis Cancer and Breast Institute-South City, St Louis
Missouri Baptist Outpatient Center-Sunset Hills, Sunset Hills
Missouri Baptist Medical Center, St Louis
Mercy Hospital Saint Louis, St Louis
Parkland Health Center-Bonne Terre, Bonne Terre
Sainte Genevieve County Memorial Hospital, Sainte Genevieve
Saint Francis Medical Center, Cape Girardeau
Southeast Cancer Center, Cape Girardeau
The University of Kansas Cancer Center-Lee's Summit, Lee's Summit
Truman Medical Center, Kansas City
The University of Kansas Cancer Center-South, Kansas City
The University of Kansas Cancer Center-North, Kansas City
Capital Region Medical Center-Goldschmidt Cancer Center, Jefferson City
Phelps County Regional Medical Center, Rolla
Saint John's Clinic-Rolla-Cancer and Hematology, Rolla
Cancer Research for the Ozarks NCORP, Springfield
Mercy Hospital Springfield, Springfield
CoxHealth South Hospital, Springfield
Lawrence Memorial Hospital, Lawrence
Olathe Medical Center, Olathe
University of Kansas Cancer Center-West, Kansas City
University of Kansas Cancer Center, Kansas City
University of Kansas Cancer Center-Overland Park, Overland Park
Cancer Center of Kansas-Manhattan, Manhattan
Saint Francis Hospital and Medical Center - Topeka, Topeka
Cancer Center of Kansas - Fort Scott, Fort Scott
Cancer Center of Kansas - Chanute, Chanute
Via Christi Hospital-Pittsburg, Pittsburg
Newman Regional Health, Emporia
Cancer Center of Kansas - El Dorado, El Dorado
Cancer Center of Kansas-Kingman, Kingman
Cancer Center of Kansas - Newton, Newton
Cancer Center of Kansas - Pratt, Pratt
Cancer Center of Kansas - Wellington, Wellington
Cancer Center of Kansas - Winfield, Winfield
Associates In Womens Health, Wichita
Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita
Cancer Center of Kansas - Wichita, Wichita
Via Christi Regional Medical Center, Wichita
Wichita NCI Community Oncology Research Program, Wichita
Cancer Center of Kansas-Independence, Independence
Cancer Center of Kansas - Parsons, Parsons
Cancer Center of Kansas - Salina, Salina
Salina Regional Health Center, Salina
Cancer Center of Kansas - McPherson, McPherson
Saint Rose Ambulatory and Surgery Center, Great Bend
Hays Medical Center, Hays
Cancer Center of Kansas - Dodge City, Dodge City
Saint Catherine Hospital, Garden City
Cancer Center of Kansas-Liberal, Liberal
University of Oklahoma Health Sciences Center, Oklahoma City
The Methodist Hospital System, Houston
The Don and Sybil Harrington Cancer Center, Amarillo
University of Colorado Cancer Center - Anschutz Cancer Pavilion, Aurora
Memorial Hospital Colorado Springs, Colorado Springs
Big Horn Basin Cancer Center, Cody
Billings Clinic-Cody, Cody
Rocky Mountain Oncology, Casper
Welch Cancer Center, Sheridan
Saint Alphonsus Cancer Care Center-Boise, Boise
Kootenai Medical Center, Coeur d'Alene
Kootenai Cancer Center, Post Falls
Kootenai Cancer Clinic, Sandpoint
Huntsman Cancer Institute/University of Utah, Salt Lake City
University of New Mexico Cancer Center, Albuquerque
Christus Saint Vincent Regional Cancer Center, Santa Fe
Cancer and Blood Specialists-Henderson, Henderson
Comprehensive Cancer Centers of Nevada - Henderson, Henderson
Las Vegas Cancer Center-Henderson, Henderson
21st Century Oncology - Henderson, Henderson
Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson
University Medical Center of Southern Nevada, Las Vegas
Cancer and Blood Specialists-Shadow, Las Vegas
Nevada Cancer Research Foundation CCOP, Las Vegas
Radiation Oncology Centers of Nevada Central, Las Vegas
21st Century Oncology, Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway, Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-San Martin, Las Vegas
Radiation Oncology Centers of Nevada Southeast, Las Vegas
Cancer Therapy and Integrative Medicine, Las Vegas
Cancer and Blood Specialists-Tenaya, Las Vegas
Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Tenaya, Las Vegas
Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas
21st Century Oncology - Fort Apache, Las Vegas
Cancer and Blood Specialists-Fort Apache, Las Vegas
Comprehensive Cancer Centers of Nevada, Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills, Las Vegas
Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas
21st Century Oncology - Vegas Tenaya, Las Vegas
Kaiser Permanente Los Angeles Medical Center, Los Angeles
Los Angeles County-USC Medical Center, Los Angeles
USC / Norris Comprehensive Cancer Center, Los Angeles
Kaiser Permanente-Cadillac, Los Angeles
Kaiser Permanente-Bellflower, Bellflower
Kaiser Permanente - Harbor City, Harbor City
City of Hope Comprehensive Cancer Center, Duarte
Kaiser Permanente, Woodland Hills
Kaiser Permanente - Panorama City, Panorama City
Kaiser Permanente-Baldwin Park, Baldwin Park
Kaiser Permanente-San Marcos, San Marcos
Kaiser Permanente-San Diego Mission, San Diego
Kaiser Permanente-San Diego Zion, San Diego
Kaiser Permanente Hospital, Fontana
Kaiser Permanente-Riverside, Riverside
Kaiser Permanente-Irvine, Irvine
Kaiser Permanente-Anaheim, Anaheim
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Mills - Peninsula Hospitals, Burlingame
Palo Alto Medical Foundation-Camino Division, Mountain View
Palo Alto Medical Foundation-Gynecologic Oncology, Mountain View
Palo Alto Medical Foundation-Sunnyvale, Sunnyvale
California Pacific Medical Center-Pacific Campus, San Francisco
Palo Alto Medical Foundation Health Care, Palo Alto
Sutter Solano Medical Center/Cancer Center, Vallejo
Alta Bates Summit Medical Center-Herrick Campus, Berkeley
Sutter Cancer Research Consortium, Novato
Palo Alto Medical Foundation-Santa Cruz, Santa Cruz
Memorial Medical Center, Modesto
Sutter Pacific Medical Foundation, Santa Rosa
Sutter Auburn Faith Hospital, Auburn
Sutter Davis Hospital, Davis
Sutter Roseville Medical Center, Roseville
Sutter General Hospital, Sacramento
University of California Davis Comprehensive Cancer Center, Sacramento
Fremont - Rideout Cancer Center, Marysville
Clackamas Radiation Oncology Center, Clackamas
Providence Willamette Falls Medical Center, Oregon City
Providence Newberg Medical Center, Newberg
Providence Portland Medical Center, Portland
Providence Milwaukie Hospital, Milwaukie
Providence Saint Vincent Medical Center, Portland
Oregon Health and Science University, Portland
PeaceHealth Saint John Medical Center, Longview
PeaceHealth Southwest Medical Center, Vancouver
Alaska Breast Care and Surgery LLC, Anchorage
Alaska Women's Cancer Care, Anchorage
Anchorage Oncology Centre, Anchorage
Katmai Oncology Group, Anchorage
Providence Alaska Medical Center, Anchorage
Smilow Cancer Hospital-Derby Care Center, Derby
Medical Oncology and Hematology Group PC-Guilford, Guilford
Smilow Cancer Hospital Care Center at Saint Francis, Hartford
Yale University, New Haven
Yale-New Haven Hospital North Haven Medical Center, North Haven
Smilow Cancer Hospital-Orange Care Center, Orange
Charlotte Hungerford Hospital Center for Cancer Care, Torrington
Smilow Cancer Hospital-Waterbury Care Center, Waterbury
Boston Medical Center, Boston
Lahey Hospital and Medical Center, Burlington
Saint Joseph Mercy Hospital, Ann Arbor
Las Vegas Cancer Center-Medical Center, Las Vegas
Atrium Medical Center-Middletown Regional Hospital, Franklin
Swedish Medical Center-First Hill, Seattle
National Cancer Institute (NCI)
NIH