40
Participants
Start Date
February 28, 2015
Primary Completion Date
July 31, 2015
Study Completion Date
August 31, 2016
Nebulised citric acid in serial dilutions
Citric acid will be delivered in serial dilutions as per the clinical trials unit standard operating procedure for cough challenge using KoKo Digidoser, based on ERS guidelines. Challenge will be repeated until C5 (5 coughs in 30 seconds following challenge) is elicited.
Nebulised ATP solution in serial dilutions
ATP solution will be delivered in serial dilutions as per the clinical trials unit standard operating procedure for cough challenge using KoKo Digidoser, based on ERS guidelines. Challenge will be repeated until C5 (5 coughs in 30 seconds following challenge) is elicited.
Nebulised TRPA1 agonist solution in serial dilutions
TRPA1 agonist will be delivered in serial dilutions as per the clinical trials unit standard operating procedure for cough challenge using KoKo Digidoser, based on ERS guidelines. Challenge will be repeated until C5 (5 coughs in 30 seconds following challenge) is elicited.
Hull Clinical Trials Unit, Respiratory academic department, Cottingham
Hull University Teaching Hospitals NHS Trust
OTHER_GOV