22
Participants
Start Date
September 30, 2013
Primary Completion Date
September 30, 2016
Study Completion Date
January 31, 2017
Hydroxyproline and Leucine
Subjects will be infused with 13C5-hydroxyproline and 2H3-leucine for 6 hrs in the CRTU. The metabolic flux of 2H3-leucine has been well characterized, and is used as a control when studying the metabolism of trace infusions of labeled amino acids 3. Blood samples will be obtained every 30 min to determine the enrichment of plasma with 13C5-hydroxyproline and 2H3-leucine. Urine collections will be obtained hourly. The fluxes of whole body hydroxyproline and leucine will be calculated
Mayo Clinic Hyperoxaluria Center, Rochester
Lead Sponsor
National Institutes of Health (NIH)
NIH
Rare Diseases Clinical Research Network
NETWORK
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Mayo Clinic
OTHER