Non-sedation Versus Sedation With a Daily Wake-up Trial in Critically Ill Patients Receiving Me-chanical Ventilation - Effects on Cognitive Function

NACompletedINTERVENTIONAL
Enrollment

205

Participants

Timeline

Start Date

January 31, 2014

Primary Completion Date

June 30, 2017

Study Completion Date

March 31, 2019

Conditions
DeliriumCognition Disorders
Interventions
OTHER

Non-sedation

Patients are awake or have natural sleep during mechanical ventilation. Pain is treated with morphine iv.

OTHER

Control: Sedation

Continuous iv-sedation (propofol first 48 hours, from then midazolam) to Ramsey 3-4 with a daily wake up attempt, where sedation is stopped until patient is awake.

Trial Locations (1)

6000

Lillebaelt Hospital, Kolding, Intensive Care Unit, Kolding

All Listed Sponsors
collaborator

Kolding Sygehus

OTHER

collaborator

University of Southern Denmark

OTHER

collaborator

The Danish Council for Strategic Research

OTHER

lead

Palle Toft

OTHER

NCT02035436 - Non-sedation Versus Sedation With a Daily Wake-up Trial in Critically Ill Patients Receiving Me-chanical Ventilation - Effects on Cognitive Function | Biotech Hunter | Biotech Hunter