Efficacy and Safety of the Combination Therapy of Dabrafenib and Trametinib in Subjects With BRAF V600E- Mutated Rare Cancers

PHASE2CompletedINTERVENTIONAL
Enrollment

206

Participants

Timeline

Start Date

March 12, 2014

Primary Completion Date

December 10, 2021

Study Completion Date

December 10, 2021

Conditions
Cancer
Interventions
DRUG

Dabrafenib

A 150 mg twice daily capsule administered orally on a continuous basis.

DRUG

Trametinib

A 2 mg once daily tablet administered orally on a continuous basis.

Trial Locations (41)

1090

Novartis Investigative Site, Vienna

Novartis Investigative Site, Jette

2100

Novartis Investigative Site, Copenhagen

4020

Novartis Investigative Site, Linz

5020

Novartis Investigative Site, Salzburg

6020

Novartis Investigative Site, Innsbruck

10016

Novartis Investigative Site, New York

13353

Novartis Investigative Site, Berlin

20132

Novartis Investigative Site, Milan

20133

Novartis Investigative Site, Milan

20141

Novartis Investigative Site, Milan

20246

Novartis Investigative Site, Hamburg

20892

Novartis Investigative Site, Bethesda

28041

Novartis Investigative Site, Madrid

31059

Novartis Investigative Site, Toulouse

33076

Novartis Investigative Site, Bordeaux

37203

Novartis Investigative Site, Nashville

44093

Novartis Investigative Site, Nantes

44805

Novartis Investigative Site, Saint-Herblain

68167

Novartis Investigative Site, Mannheim

69120

Novartis Investigative Site, Heidelberg

69373

Novartis Investigative Site, Lyon

72205

Novartis Investigative Site, Little Rock

77030

Novartis Investigative Site, Houston

79106

Novartis Investigative Site, Freiburg im Breisgau

90404

Novartis Investigative Site, Santa Monica

94805

Novartis Investigative Site, Villejuif

02114

Novartis Investigative Site, Boston

02215

Novartis Investigative Site, Boston

M5G 2M9

Novartis Investigative Site, Toronto

277-8577

Novartis Investigative Site, Chiba

104-0045

Novartis Investigative Site, Tokyo

1066 CX

Novartis Investigative Site, Amsterdam

1081 HV

Novartis Investigative Site, Amsterdam

3015 GD

Novartis Investigative Site, Rotterdam

3584 CX

Novartis Investigative Site, Utrecht

0310

Novartis Investigative Site, Oslo

03080

Novartis Investigative Site, Seoul

06273

Novartis Investigative Site, Seoul

08035

Novartis Investigative Site, Barcelona

171 76

Novartis Investigative Site, Stockholm

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY