Efficacy and Safety of Allogeneic Mesenchymal Precursor Cells (Rexlemestrocel-L) for the Treatment of Heart Failure.

PHASE3CompletedINTERVENTIONAL
Enrollment

566

Participants

Timeline

Start Date

February 14, 2014

Primary Completion Date

May 29, 2020

Study Completion Date

May 29, 2020

Conditions
Chronic Heart Failure
Interventions
BIOLOGICAL

Allogeneic Mesenchymal Precursor Cells (MPCs)

Rexlemestrocel-L consists of human bone marrow-derived allogeneic MPCs isolated from bone mononuclear cells with anti-STRO-3 antibodies, expanded ex vivo, and cryopreserved

OTHER

Sham Comparator

The sham procedure will be staged to script and will not include actual cardiac mapping or delivery of rexlemestrocel-L.

Trial Locations (59)

10032

Mesoblast Investigational Site 10776 - Columbia University Medical Center, New York

15213

Mesoblast Investigational Site 10774 - University of Pittsburgh, Pittsburgh

18103

Mesoblast Investigational Site 10785 - Lehigh Valley Hospital, Allentown

19104

Mesoblast Investigational Site 13261 - University of Pennsylvania, Philadelphia

19140

Mesoblast Investigational Site 10767 - Temple University Hospital, Philadelphia

27710

Mesoblast Investigational Site 10781 - Duke University, Durham

28203

Mesoblast Investigational Site 13026 - Sanger Heart and Vascular Institute, Carolinas Healthcare System, Charlotte

30322

Mesoblast Investigational Site 13027 - Emory University School of Medicine, Atlanta

30912

Mesoblast Investigational Site 10765 - Georgia Regents University, Augusta

32209

Mesoblast Investigational Site 13273 - University of Florida Health, Jacksonville

32610

Mesoblast Investigational Site 10760 - Shands Hospital, University of Florida, Gainesville

33215

Mesoblast Investigational Site 10768 - University of Miami, Miami

33435

Mesoblast Investigational Site 13267 - Bethesda Heart Hospital, Boynton Beach

33613

Mesoblast Investigational Site 13264 - Florida Hospital Pepin Heart Institute, Tampa

33756

Mesoblast Investigational Site 10780 - Morton Plant Hospital, Clearwater

35211

Mesoblast Investigational Site 10757 - Cardiology, P.C., Birmingham

35233

Mesoblast Investigational Site 13262 - University of Alabama at Birmingham Hospital, Birmingham

38125

Mesoblast Investigational Site 10777 - Stern Cardiovascular Foundation, Germantown

40202

Mesoblast Investigational Site 13022 - University of Louisville, Louisville

40536

Mesoblast Investigational Site 10783 - Gill Heart Institute, University of Kentucky, Lexington

43214

Mesoblast Investigational Site 13278 - OhioHealth Research Institute, Columbus

45219

Mesoblast Investigational Site 10758 - The Christ Hospital, Cincinnati

45267

Mesoblast Investigational Site 10770 - University of Cincinnati, Cincinnati

48602

Mesoblast Investigational Site 10766 - Michigan Cardiovascular Institute, Saginaw

52242

Mesoblast Investigational Site 13030 - University of Iowa, Iowa City

53215

Mesoblast Investigational Site 10769 - Aurora Healthcare, Milwaukee

53792

Mesoblast Investigational Site 10764 - University of Wisconsin, Madison

54401

Mesoblast Investigational Site 10789 - Aspirus Research Institute, Wausau

55407

Mesoblast Investigational Site 10762 - Minneapolis Heart Institute, Minneapolis

55905

Mesoblast Investigational Site 10761 - Mayo Clinic, Rochester

60612

Mesoblast Investigational Site 10772 - University Cardiologist, Rush University Medical Center, Chicago

75226

Mesoblast Investigational Site 13274 - Soltero CV Research Center, Baylor Scott & White Research Institute, Dallas

77030

Mesoblast Investigational Site 10755 - Texas Heart Institute, Houston

Mesoblast Investigational Site 13268 - Houston Methodist Hospital, Houston

78756

Mesoblast Investigational Site 13024 - Austin Heart, PLLC, Austin

84132

Mesoblast Investigational Site 10763 - University Hospital, Salt Lake City

85054

Mesoblast Investigational Site 10756 - Mayo Clinic, Phoenix

85206

Mesoblast Investigational Site 10786 - Cardiovascular Associates of Mesa, Mesa

85297

Mesoblast Investigational Site 10779 - Mercy Gilbert Medical Center, Gilbert

85724

Mesoblast Investigational Site 13023 - University of Arizona Medical Center, Tucson

90045

Mesoblast Investigational Site 13265 - University of California, Los Angeles, Los Angeles

90211

Mesoblast Investigational Site 10775 - Cedars-Sinai Medical Care Foundation, Los Angeles

92037

Mesoblast Investigational Site 10754 - University of California, San Diego, La Jolla

Mesoblast Investigational Site 10759 - Scripps Clinic, La Jolla

92868

Mesoblast Investigational Site 10778 - Orange County Cardiology, Orange

93030

Mesoblast Investigational Site 13031 - St. John's Regional Medical Center, Oxnard

94305

Mesoblast Investigational Site 13275 - Stanford University Hospital, Stanford

98122

Mesoblast Investigational Site 10771 - Heart & Vascular Research, Swedish Medical Center, Seattle

Unknown

Mesoblast Investigational Site 13280, Orlando

Mesoblast Investigational Site 13266, New Orleans

Mesoblast Investigational Site 10782, Boston

Mesoblast Investigational Site 13281, Las Vegas

Mesoblast Investigational Site 10773, Cleveland

Mesoblast Investigational Site 13277, Philadelphia

Mesoblast Investigational Site 13279, Milwaukee

Mesoblast Investigational Site 11027, Edmonton

07112

Mesoblast Investigational Site 13263 - RWJ Barnabas Heart Center, Newark

V8R 4R2

Mesoblast Investigational Site 11024 - Victoria Heart Institute Foundation, Victoria

M5B 1W8

Mesoblast Investigational Site 11025 - St. Michael's Hospital, Toronto

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Mesoblast, Inc.

INDUSTRY