Novel Combinations of CC-122, CC-223, CC-292, and Rituximab in Diffuse Large B-cell Lymphoma and Follicular Lymphoma

PHASE1TerminatedINTERVENTIONAL
Enrollment

174

Participants

Timeline

Start Date

December 18, 2013

Primary Completion Date

December 12, 2023

Study Completion Date

December 12, 2023

Conditions
Lymphoma, Large B-Cell, Diffuse
Interventions
DRUG

CC-122

2mg or 3 mg administered orally once daily

DRUG

CC-223

20mg or 30mg administered orally once daily.

DRUG

Rituximab

375 mg/m2 administered intravenously once every 28 days

DRUG

CC-122

2mg or 3mg administered orally once daily.

DRUG

CC-292

500 mg twice a day administered orally.

DRUG

Rituximab

375 mg/m2 administered intravenously once every 28 days

DRUG

CC-223

20mg or 30mg per day administered orally daily.

DRUG

CC-292

500 mg twice a day administered orally.

DRUG

Rituximab

375 mg/m2 administered intravenously once every 28 days

Trial Locations (16)

10126

Local Institution - 201, Turin

20089

Local Institution - 200, Rozzano (MI)

20133

Local Institution - 202, Milan

33076

Local Institution - 102, Bordeaux

33612

Local Institution - 005, Tampa

37203

Local Institution - 001, Nashville

53792

Local Institution - 007, Madison

55905

Mayo Clinic, Rochester

60611

Northwestern University, Chicago

69373

Local Institution - 101, Lyon

94305

Stanford Cancer Center, Stanford

94805

Local Institution - 100, Villejuif

06510

Yale Cancer Center, New Haven

77030-400

MD Anderson Cancer Center, Houston

T6G 1Z2

Local Institution - 402, Edmonton

M5G 2M9

Local Institution - 400, Toronto

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Celgene

INDUSTRY