Efficacy and Safety Study of Satralizumab (SA237) as Add-on Therapy to Treat Participants With Neuromyelitis Optica (NMO) and NMO Spectrum Disorder (NMOSD)

PHASE3CompletedINTERVENTIONAL
Enrollment

85

Participants

Timeline

Start Date

February 20, 2014

Primary Completion Date

June 6, 2018

Study Completion Date

December 23, 2021

Conditions
Neuromyelitis Optica (NMO)NMO Spectrum Disorder (NMOSD)
Interventions
DRUG

Satralizumab

Satralizumab will be administered subcutaneously (SC) at Weeks 0, 2, and 4, and thereafter once every 4 weeks (Q4W).

DRUG

Placebo

Placebo will be administered subcutaneously (SC) at Weeks 0, 2, and 4, and thereafter once every 4 weeks (Q4W).

DRUG

Baseline Treatment

As specified in the protocol, one of the following drugs at a stable dose is required as monotherapy for baseline treatment during the double-blind period: azathioprine (AZA); mycophenolate mofetil (MMF); or oral corticosteroids (CS). For participants aged 12 to 17 years at the time of informed consent, baseline treatment with AZA or MMF in combination with oral CS is also permitted. Change or termination of baseline treatment is only permitted during the open-label extension period.

Trial Locations (40)

100

National Taiwan University Hospital; Neurology, Taipei

189

Azienda Ospedaliera Sant'Andrea-Universitr di Roma La Sapien, Rome

704

National Cheng Kung University Hospital; Neurology, Tainan City

1204

Jahn Ferenc Dél-Pesti Kórház, Budapest

10117

NeuroCure Clinical Research Center (NCRC), Berlin

11217

Taipei Veterans General Hospital-Neurology, Taipei

20132

Ospedale San Raffaele, Milan

28040

Hospital Clinico San Carlos; Servicio de Nefrologia, Madrid

33305

Chang Gung Medical Foundation - LinKou Chang Gung Memorial Hospital - Neurology, Kwei Shen

35233

Children's Hospital of Alabama, Birmingham

40225

Heinrich-Heine Universitätsklinik Düsseldorf, Düsseldorf

40447

China Medical University Hospital; Neurology - Taichung, Taichung

44791

St. Josef-Hospital, Klinik für Neurologie, Bochum

49100

"KZ Dnipropetrovska oblasna dytiacha klinichna likarnia DOR", Dnipropetrovsk

61000

Kharkivska miska dytiacha likarnia # 5, Kharkiv

67091

Hopital de Hautepierre CHRU de Strasbourg, Strasbourg

90015

Fond. Ist. S. Raffaele - giglio, Cefalù

95123

PO G.Rodolico, AOU Policlinico-Vittorio Emanuele Catania, Catania

113-8431

Juntendo University Hospital; Neurology, Bunkyō City

812-8582

Kyushu University Hospital; Neurology, Fukuoka

960-1295

Fukushima Medical University Hospital; Neurology, Fukushima

890-8520

Kagoshima University Medical And Dental Hospital; Neurology and Geriatorics, Kagoshima

951-8520

Niigata University Medical and Dental Hospital; Neurology, Niigata

589-8511

Kindai University Hospital; Neurology, Osaka

980-8574

Tohoku University Hospital; Neurology, Sendai

162-8666

Tokyo Women's Medical University Hospital; Neurology, Shinjuku-ku

565-0871

Osaka University Hospital; Neurology, Suita

187-8551

National Center of Neurology and Psychiatry, Tokyo

40-123

NZOZ Wielospecjalistyczna Poradnia Lekarska SYNAPSIS, Katowice

40-571

M.A. - LEK A. M. Maciejowscy SC. Centrum Terapii SM, Katowice

40-684

Centrum Medyczne Dendryt, Katowice

20-954

Samodzielny Publiczny Szpital Kliniczny nr 4 w Lublinie, Lublin

60-355

Szpital Kliniczny im. H.Swiecickiego UM w Poznaniu, Późna

02-097

Samodzielny Publiczny Centralny Szpital Klinicznyi, Warsaw

Unknown

Instytut Psychiatrii i Neurologii, Warsaw

08036

Hospital Clinic de Barcelona, Barcelona

CF14 4XW

University Hospital of Wales; Dept of Neurology, Cardiff

OX3 9DU

John Radcliffe Hospital; Neurosciences, Chinnor

WC1N 3BG

The National Hospital for Neurology & Neurosurgery, London

WC1N 3JH

Great Ormond Street Hospital For Children; Neurology, London

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Chugai Pharmaceutical

INDUSTRY

lead

Hoffmann-La Roche

INDUSTRY