NOn-invasive Repeated THerapeutic STimulation for Aphasia Recovery

NACompletedINTERVENTIONAL
Enrollment

63

Participants

Timeline

Start Date

December 31, 2013

Primary Completion Date

March 31, 2018

Study Completion Date

March 31, 2018

Conditions
Aphasia
Interventions
DEVICE

rTMS

Low frequency (1Hz) repetitive transcranial magnetic stimulation (rTMS) over the center of the right Pars Triangularis for 15 minutes (900 pulses) prior to each Speech-Language therapy session. Stimulation intensity will be set at 90% of the resting motor threshold (RMT) of the left first dorsal interosseous (FDI) muscle.

DEVICE

tDCS

2mA cathodal transcranial direct current stimulation (tDCS) over the right Pars Triangularis. The anode will be placed on the forehead over the contralateral eye. tDCS will start immediately before the speech-language therapy session and last throughout the session.

DEVICE

Sham rTMS

Low frequency (1Hz) repetitive transcranial magnetic stimulation (rTMS) over the Vertex for 15 minutes (900 pulses) prior to each Speech-Language therapy session. Stimulation intensity will be set at 10% of the resting motor threshold (RMT) of the left first dorsal interosseous (FDI) muscle.

DEVICE

Sham tDCS

Sham cathodal transcranial direct current stimulation (tDCS) over the right Pars Triangularis. The anode will be placed on the forehead over the contralateral eye. To elicit the typical skin sensation of real tDCS (tingling sensation on the skin when tDCS is turned on and off), the current will be turned on for 30 seconds and then turned off for the duration of the speech-language therapy session. The same procedure will be done at the end of the session.

Trial Locations (6)

10605

Burke-Cornell Medical Research Institute, White Plains

50931

Max-Planck-Institut für neurologische Forschung, Cologne

M4N 3M5

Sunnybrook Research Institute, Toronto

M5G 2C4

Toronto Rehabilitation Institute - UHN, Toronto

H2L 4M1

CHUM Notre-Dame, Montreal

H3T 1E2

Jewish General Hospital, Montreal

All Listed Sponsors
lead

Dr. Alexander Thiel

INDIV

NCT02020421 - NOn-invasive Repeated THerapeutic STimulation for Aphasia Recovery | Biotech Hunter | Biotech Hunter