80
Participants
Start Date
December 31, 2013
Primary Completion Date
December 31, 2015
Study Completion Date
December 31, 2015
Roflumilast escalation dosage
"This is a randomized, prospective, open label, comparative study to assess whether the administration of roflumilast by dose escalation varies the incidence of discontinuations due to adverse events when compared with the usual dosage in severe and very severe COPD patients.~Roflumilast 250 μg once daily for 4 weeks and then increased dose of Roflumilast 500 μg once daily for 12 weeks"
Roflumilast conventional dosage
Roflumilast 500 μg once daily for 12 weeks
Department of Pulmonary and Critical Care Medicine and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul
Lead Sponsor
Asan Medical Center
OTHER