A Study of DKN-01 in Combination With Paclitaxel or Pembrolizumab

PHASE1CompletedINTERVENTIONAL
Enrollment

151

Participants

Timeline

Start Date

May 5, 2014

Primary Completion Date

July 19, 2019

Study Completion Date

January 11, 2021

Conditions
Esophageal NeoplasmsAdenocarcinoma of the Gastroesophageal JunctionGastroesophageal CancerSquamous Cell CarcinomaGastric Adenocarcinoma
Interventions
DRUG

DKN-01 150 mg

Administered by IV infusion

DRUG

Paclitaxel

Administered by IV infusion

DRUG

Pembrolizumab

Administered by IV infusion

DRUG

DKN-01 300 mg

Administered by IV infusion

Trial Locations (10)

27710

Duke University, Durham

37203

Tennessee Oncology / Sarah Cannon Research Institute, Nashville

37232

Vanderbilt University / VICC, Nashville

60611

Northwestern University, Chicago

75251

Mary Crowley Cancer Center, Dallas

78229

CTRC @ The University of Texas Health Science Center at San Antonio, San Antonio

90025

Cedars Sinai Medical Care Foundation, Los Angeles

06520

Smilow Cancer Hospital at Yale - New Haven, New Haven

02215

Dana Farber Cancer Institute, Boston

Massachusetts General Hospital, Boston

Sponsors
All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Leap Therapeutics, Inc.

INDUSTRY