Study to Evaluate the Efficacy and Safety of Oxabact (OC5) in Patients With Primary Hyperoxaluria

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

28

Participants

Timeline

Start Date

December 31, 2013

Primary Completion Date

January 31, 2015

Study Completion Date

January 31, 2015

Conditions
Primary Hyperoxaluria
Interventions
BIOLOGICAL

Oxabact OC5 capsules

The dose will be not less than (NLT) 1E+09 colony forming units (CFU) twice daily for 8 to 10 weeks. The dose (an enteric-coated size 4 capsule) will be administered orally with breakfast and dinner.

DRUG

Placebo capsules

An enteric-coated placebo capsule manufactured to mimic the OC5 capsule. The capsule will be administered orally with breakfast and dinner twice daily for 8 to 10 weeks.

Trial Locations (8)

33076

Hôpital des Enfants, Centre de référence maladies rénales rares du Sud-Ouest (SORARE), CHU de Bordeaux, Bordeaux

75015

Hôpital Necker-Enfants Malades,Centre de référence des Maladies Rénales Héréditaires de l'Enfant et de l'Adulte (MARHEA), Paris

75945

Hôpital Robert-Debré, Néphrologie Pédiatrique, Paris

69677 Bron

Hôpital Femme Mère Enfant, Lyon - Paediatric Dept, Lyon

DE-53113

Universitätsklinikum Bonn, Dept of Paediatric Nephrology, Bonn

B4 6NH

Birmingham Children's Hospital NHS Foundation Trust - Dept of Nephrology, Birmingham

NW3 2QG

Royal Free Hospital -UCL Centre for Nephrology, London

WCIN 3JH

Great Ormond Street Hospital for Children NHS Trust, London

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

FP7-SME-2013 Research for the benefit of SMEs program

UNKNOWN

lead

OxThera

INDUSTRY

NCT02012985 - Study to Evaluate the Efficacy and Safety of Oxabact (OC5) in Patients With Primary Hyperoxaluria | Biotech Hunter | Biotech Hunter